补体因子 B 抑制剂 iptacopan 通过基于补体的免疫调节驱动胰腺癌微环境的抗肿瘤作用
Complement factor B blockade by iptacopan drives antitumor complement-based immunomodulation in pancreatic cancer microenvironment.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
DISEASE HUB
FOR TREATMENT
登记显示招募中的试验排在最前,共 6 项。同一状态内中国中心优先;具体中心是否开放须核实。信息来自 ClinicalTrials.gov、CDE 与 ChiCTR 公开登记。能否入组、费用与可及性,以登记原文和主治医生判断为准。
FOR RESEARCH
Complement factor B blockade by iptacopan drives antitumor complement-based immunomodulation in pancreatic cancer microenvironment.
B Cells and Tumor Immunometabolism: Emerging Insights into Immune Regulation and Therapeutic Resistance.
Spatial Configuration of Pancreatic Cancer Is Associated with Disease Recurrence after Neoadjuvant Therapy and Curative-Intent Resection.
从标准 H&E 切片量化的残留癌-间质拓扑结构在 PDAC 新辅助治疗后产生独立预后信号,为空间风险提供细胞免疫相关性依据,并推动前瞻性验证及空间信息指导的辅助治疗策略。
Mechanism and clinical relevance of metabolic-immune cross-talk in pancreatic tumor microenvironment.
Real-time monitoring of CAR T cell dynamics in tumor patient-derived organoids using the OrganoIDNet algorithm.
通过将类器官-免疫共培养与 OrganoIDNet 驱动的活细胞成像相结合,我们建立了一种自动化纵向成像检测方法,用于评估 PDAC PDO 中 CAR-T 细胞介导的反应。该检测方法能够在多个效靶比下连续定量类器官数量和面积,并结合基于图像的 T 细胞邻近性评估。这些测量提供了观察期内抗原依赖性细胞毒作用和空间关联的时间分辨信息,支持其作为 CAR-T 细胞开发和未来个性化免疫治疗研究的临床前平台的潜在用途。
IL-10's contextual role in cytotoxic antitumor immunity: evidence, controversies, and therapeutic translation.
Corrigendum to "Wang X, Wang R, Lin X et al. Comparative evaluation of chemotherapy and CAR-T cell therapy in genetically engineered self-sustaining p
Targeting Reactive Species Stress and Nutrient Sensing to Enhance NK-Cell Function: Mechanistic Strategies for Overcoming Pancreatic Cancer Progressio
Clinical translation of mRNA-based cancer vaccines for solid tumors.
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