抗 CD22/CD19 CAR-T 细胞疗法 CART2219.1 在成人和儿童复发/难治性 B-ALL 中的 I/II 期试验
A Phase I/II Trial of Anti-CD22/CD19 CAR-T Cell Therapy, CART2219.1, in Adult and Pediatric Relapsed/Refractory B-ALL.
在一项多中心I/II期试验中,所有患者(n=11;7名儿童,4名成人)在第28天均达到完全缓解(91%为微小残留病阴性)。
FRONTIER PAPERS
A Phase I/II Trial of Anti-CD22/CD19 CAR-T Cell Therapy, CART2219.1, in Adult and Pediatric Relapsed/Refractory B-ALL.
在一项多中心I/II期试验中,所有患者(n=11;7名儿童,4名成人)在第28天均达到完全缓解(91%为微小残留病阴性)。
Society for Immunotherapy of Cancer (SITC) clinical practice guideline on immunotherapy for the treatment of acute leukemia, version 2.0.
急性白血病是一种影响所有年龄段的血液系统恶性肿瘤。
Leukemic Stem Cell-Targeted Liposomal Nanoimmunotherapy Reverses Immune Evasion and Inhibits Fusion Oncoprotein-Driven Acute Myeloid Leukemia by Silen
急性髓系白血病(AML)是一种由白血病干细胞和免疫逃逸驱动的常见且侵袭性强的血液系统恶性肿瘤。
Targeting BLVRB Overcomes Immunosuppression and Potentiates Immunotherapy in Monocytic Acute Myeloid Leukemia.
急性髓系白血病(AML)以显著免疫抑制为特征,限制了免疫治疗的疗效。
High-dimensional spectral flow cytometry uncovers progressive T-cell exhaustion and myeloid cell reprogramming in a CLL mouse model.
我们的研究结果证明了在Eµ-TCL1小鼠模型中,向抑制性微环境的逐步转变涉及先天性和适应性免疫区室,为理解CLL中的免疫失败提供了框架,并为恢复抗白血病免疫的策略提供了信息。
Next-generation antibody-based therapeutics in cancer: antibody-drug conjugates bispecific antibodies across hematologic malignancies and solid tumors
肿瘤学的治疗范式正在经历由抗体药物偶联物(ADC)和双特异性抗体(bsAb)驱动的深刻变革。
CD84 expression stratifies venetoclax response and reveals a targetable vulnerability in resistant acute myeloid leukemia.
我们的研究结果表明,CD84介导的SESN2上调促进了venetoclax耐药,并可能成为提高AML治疗疗效的潜在治疗靶点。
CAR T-Cell Therapy in Acute Lymphoblastic Leukemia-Is Limited Persistence Enough?
Bicistronic CD19/CD22 CAR T-Cell Therapy in Pediatric B-Cell Acute Lymphoblastic Leukemia: A Nonrandomized Clinical Trial.
在这项非随机临床试验中,双顺反子CD19/CD22 CAR T细胞疗法在儿童B-ALL中诱导了高比例的微小残留病阴性缓解,并具有持久的EFS。这些发现支持在前瞻性试验中进一步评估。
CAR T Cells Targeting an Intracellular Leukemia Antigen Promiscuously Presented by Diverse HLA-II Alleles.
UNLABELLED:嵌合抗原受体(CAR)技术使 T 细胞能够有效识别并靶向谱系特异性表面抗原,从而彻底改变了 B 细胞恶性肿瘤的治疗。
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