食管癌

整合血浆来源的循环蛋白与多组学方法以识别食管腺癌的潜在治疗靶点

Integrating plasma-derived circulating proteins with multi-omics approaches to identify potential therapeutic targets for esophageal adenocarcinoma.

Hif3a 杂合性种系缺失加重食管鳞状细胞癌的发展

Heterozygous germline deletion in Hif3a exacerbates esophageal squamous cell carcinoma development.

整合空间免疫表型分析识别出食管鳞状细胞癌中一个抑制性浸润的高危亚组

Integrated Spatial Immune Phenotyping Identifies a Suppressive-infiltrated High-risk Subgroup in Esophageal Squamous Cell Carcinoma.

对 ESCC 中免疫浸润、空间分布及抑制-效应平衡的综合评估识别出临床上不同的免疫表型。抑制性浸润表型代表一种高危免疫微环境亚组，与不良生存独立相关。

整合单细胞和基因组分析揭示 NMB 通过代谢重编程和免疫逃逸驱动食管鳞状细胞癌的转移适应

Integrative single-cell and genomic analysis reveals NMB as a driver of metastatic adaptation in esophageal squamous cell carcinoma via metabolic rewi

NMB 是 ESCC 转移适应的关键驱动因素，通过基因组进化和免疫重塑在转移定植过程中赋予肿瘤细胞生存优势，代谢适应是基因组改变的下游结果。

锌指蛋白 600 对食管癌相关 NK 细胞的细胞毒性功能至关重要

Zinc finger protein 600 is essential for the cytotoxic function of esophageal cancer-associated natural killer cells.

CD4+、CD8+和 FOXP3+TIL（肿瘤浸润淋巴细胞）及其比值与食管鳞状细胞癌临床病理参数及肿瘤出芽的关系

The Relationship of CD4+, CD8+, and FOXP3+ Tumor-Infiltrating Lymphocytes and Their Ratios With Clinicopathological Parameters and Tumor Budding in Es

对的钥匙，错的锁：TIGIT 检查点阻断与精准免疫治疗之路

The Right Key, the Wrong Lock: TIGIT Checkpoint Blockade and the Road to Precision Immunotherapy.

PVR 介导食管鳞状细胞癌对 IL21.CD276.CAR-T 治疗的耐药

PVR Mediates Resistance to IL21.CD276.CAR-T Therapy in Esophageal Squamous Cell Carcinoma.

骨髓间充质干细胞来源的外泌体 miR-93-5p 通过靶向 PD-L1 抑制食管鳞状细胞癌进展和免疫逃逸

Bone marrow mesenchymal stem cell-derived exosomal miR-93-5p suppresses esophageal squamous cell carcinoma progression and immune escape through targe

BMSC 来源的外泌体携带 miR-93-5p 可通过抑制 PD-L1 在体外 T 细胞共培养系统中抑制 ESCC 进展并逆转肿瘤免疫逃逸，这为 ESCC 的临床治疗提供了新的潜在治疗靶点和策略。

iPSC 来源的 MUC1 靶向 CAR-NK 细胞对食管鳞状细胞癌的临床前疗效

Preclinical efficacy of iPSC-derived MUC1-targeted CAR-NK cells against esophageal squamous cell carcinoma.

iPSC 来源的 MUC1 靶向 CAR-NK 细胞对人 ESCC 发挥强效且特异性的抗肿瘤作用，支持这种现货型细胞疗法的临床转化。