IL-15 在固有免疫与适应性免疫界面的反式呈递:机制及其在肿瘤免疫治疗中的转化
IL-15 trans-presentation at the innate-adaptive interface: mechanisms and translation in cancer immunotherapy.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
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IL-15 trans-presentation at the innate-adaptive interface: mechanisms and translation in cancer immunotherapy.
Fibroblast growth factor receptor 3 (FGFR3) alterations and response to immune checkpoint inhibition in metastatic urothelial carcinoma: a systematic
在接受 ICIs 治疗的患者中,FGFR3 改变与较少的疾病控制和较短的时间-事件结局相关,而 ORR 无显著差异。由于证据主要为回顾性或源自探索性生物标志物亚组,且缺乏非 ICI 对照,这些发现不能确立预测性治疗交互作用或因果性免疫治疗耐药。它们应被视为产生假设,并支持前瞻性生物标志物分层验证,包括评估 FGFR 抑制联合免疫治疗的试验。
Long-Term Outcomes and Paired Immune and Genomic Exploratory Analyses After Neoadjuvant Dose-Dense MVAC in Muscle-Invasive Bladder Cancer: A Single-Ce
Post-Treatment NLR and SII Associations with Response and Progression-Free Survival After Neoadjuvant Disitamab Vedotin Plus PD-1 Blockade in Muscle-I
Expanding indications of immune checkpoint inhibitors: a decade of success going strong.
自 2011 年以来,ICIs 几乎渗透到肿瘤学的所有领域,对多种癌症类型产生了有意义的影响。除了扩大适应症外,它们还为许多应答者提供了持久获益的潜力。在黑色素瘤、头颈部、肾脏、肝脏和尿路上皮癌中,临床试验之外的 PD-L1 检测已不再需要。PD-1 ± CTLA-4 抑制在微卫星不稳定性高癌症中的肿瘤不可知疗效已得到充分确立。在其他癌症亚群中获益有限,这凸显了生物标志物发现和治疗策略优化的必要性,包括在 ICIs 基础上加用抗体-药物
Case Report: Primed dendritic cell immunotherapy for multiple solid tumors.
Unconventional T cells in urological cancers: catch them if you can.
Decoding the role of exosomes in bladder cancer: focusing on tumor progression and immune microenvironment modulation.
Metabolic Reprogramming by Engineered Probiotics Potentiates Tumor Chemodynamic Immunotherapy.
Immune Phenotype in Urothelial Carcinoma: From Tumor Biology to Therapeutic Stratification.
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