肿瘤细胞治疗研究
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按「中国试验优先 → 正在招募 → 更新更近」排序。信息来自 ClinicalTrials.gov 与 CDE 公开登记。能否入组、费用与可及性，以登记原文和主治医生判断为准。
FOR RESEARCH
Genetic Mutation and Epigenetic Silencing Drive Antigen-Negative Relapse in CD7 CAR T-Treated T-cell Lymphoid Malignancies.
综合而言，这些发现表明，在 CD7 CAR-T 细胞疗法的选择压力下，克隆异质性和表观遗传可塑性共同驱动 T 细胞淋巴系统恶性肿瘤的抗原阴性复发。
A phase 1 feasibility trial of BE-CAR33, an "off-the-shelf" base-edited CAR33 T cell therapy for acute myeloid leukemia.
符合条件的参与者为年龄小于16岁的复发/难治性AML患者。
Forging New Pathways in Oncology: Strategic Insights from the 17th Annual Frontiers in Cancer Science Conference.
第17届癌症科学前沿（FCS）年会（2025）强调了多组学、计算生物学和祖先特异性基因组学的融合，以推进主动性癌症护理。
Anti-CD7 fratricide-resistant chimeric antigen receptor T cells for relapsed/refractory acute myeloid leukemia.
自体第二代靶向CD7的CAR-T 细胞，表达抗CD7蛋白表达阻断剂以防止自我杀伤的同室相残，被输注给3例复发/难治性CD7+急性髓系白血病儿童/年轻成人患者，结果达到可测量残留病阴性。
Targeting CD38 with bispecific antibody XmAb 18968 in patients with relapsed/refractory acute myeloid leukemia and T-cell acute lymphoblastic leukemia
22例AML（n=13）和T-ALL（n=9）患者入组，中位年龄63岁（范围31-77）。
In vivo CAR T cell generation using retargeted and functionalized lentiviral vectors with reduced immunogenicity.
尽管针对血液系统恶性肿瘤疗效显著，CAR T制造的成本和复杂性仍是更广泛患者可及性的重大障碍。
Correction: CD7 chimeric antigen receptor T cells in patients with relapsed or refractory CD7-positive acute myeloid leukemia.
Low-dose CD7 chimeric antigen receptor T cells for relapsed/refractory T-cell lymphomas: a single-arm, open-label, phase Ia/Ib study.
Efficacy, Safety, and Kinetics of Naturally Selected Anti-CD7 CAR-T Cell Therapy in T-ALL/LBL With CNS Leukemia.
TA-TMA occurring after sequential CD7 CAR-T cell therapy and allogeneic hematopoietic stem cell transplantation: a case report.
目前，CAR-T细胞治疗桥接异基因造血干细胞移植（allo-HSCT）已成为难治/复发性血液系统恶性肿瘤的关键治疗策略。
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