CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
英文原题：Tumor-Infiltrating B Cells and Tissue-Resident Memory T Cells as Prognostic Indicators in Brain Metastases Derived from Gastrointestinal Cancers.
Tumor-Infiltrating B Cells and Tissue-Resident Memory T Cells as Prognostic Indicators in Brain Metastases Derived from Gastrointestinal Cancers.
分数与星级只用于站内排序 —— 不代表疗效、安全性或个人适用性。
BM 组织中 TIB 与 TRM 的密度可作为 GIBMs 患者生存的可靠预后指标。
肿瘤浸润B细胞（TIB）和组织驻留记忆T细胞（TRM）在抗肿瘤免疫中发挥重要作用，但其对胃肠道（GI）癌症脑转移（BM）的预后意义尚不清楚。本研究旨在探讨TIB和TRM对GI癌脑转移（GIBM）的预后价值。
研究对13例患者手术切除的GIBM组织进行回顾性组织病理分析。定量检测TIL（肿瘤浸润淋巴细胞）亚群密度，包括TIB、CD4+ T细胞、CD8+CD103+ TRM和CD8+CD103-非TRM，并分析其与临床参数、总生存期（OS）及分级预后评估（GPA）的关系。
TIB和CD4+ T细胞主要聚集于肿瘤间质，尤其集中在血管周围，并形成不具备三级淋巴结构（TLS）特征的淋巴细胞簇。相较于非TRM，TRM更深入浸润肿瘤上皮。TIB密度与GPA预后预测以及脑转移诊断或手术后的总生存期均呈正相关。此外，TIB和TRM密度增加均与脑转移诊断后的生存改善相关。
脑转移组织中的TIB和TRM密度可作为GIBM患者生存的可靠预后指标。本研究为开发针对这一致命疾病的新型免疫治疗策略提供了重要见解。
Retrospective histopathological analyses were performed on surgically resected GIBM tissues from 13 patients. The densities of tumor-infiltrating lymphocytes (TIL) subsets (TIBs, CD4 + T cells, CD8 + CD103 + TRMs, and CD8 + CD103 - non-TRMs) were quantified and correlated with clinical parameters and overall survival (OS) including the Graded Prognostic Assessment (GPA).
TIBs and CD4 + T cells were predominantly accumulated in the tumor stroma, particularly around blood vessels, where they formed lymphocyte clusters without characteristics of tertiary lymphoid structures (TLSs). In contrast, TRMs more deeply infiltrated into the tumor epithelium than their counterpart non-TRMs. Positive correlations were found between TIB density and both the prognostic prediction of GPA and overall survival (OS) after BM diagnosis or surgery. Furthermore, increased densities of TIBs and TRMs were associated with enhanced survival after BM diagnosis.
TIB and TRM densities in BM tissues could serve as reliable prognostic indicators for survival in patients with GIBMs. This study provides crucial insights for the development of novel immunotherapeutic strategies against this lethal disease.
在 PubMed 查看 → 出版商原文（DOI） 全文 PDF（PMC）· 可下载 治疗专题与资料阅读指南 资料来源与翻译说明 报告译文或资料问题 →
MEMBER ACCOUNT
登录成功会直接打开下一页。
