CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
英文原题：Immunotherapy revolutionizing brain metastatic cancer treatment: personalized strategies for transformative outcomes.
Immunotherapy revolutionizing brain metastatic cancer treatment: personalized strategies for transformative outcomes.
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脑转移癌是一个重大的临床挑战，患者的治疗选择有限且预后较差。近年来，免疫治疗已成为应对脑转移的一种有前景的策略，相较于传统治疗具有明显优势。本综述探讨了肿瘤免疫治疗在脑转移癌背景下不断演变的格局，重点关注肿瘤微环境（TME）与免疫治疗方法之间复杂的相互作用。通过阐明TME内复杂的相互作用，包括免疫细胞、细胞因子和细胞外基质成分的作用，本综述强调了免疫治疗重塑脑转移治疗范式的潜力。利用免疫检查点抑制剂、细胞免疫治疗和个性化治疗策略，免疫治疗有望克服脑转移的血脑屏障和免疫抑制微环境所带来的挑战。通过对当前研究结果和未来方向的全面分析，本综述强调了免疫治疗对脑转移癌管理的变革性影响，为个性化和精准治疗干预提供了新的见解和机会。
Brain metastatic cancer poses a significant clinical challenge, with limited treatment options and poor prognosis for patients. In recent years, immunotherapy has emerged as a promising strategy for addressing brain metastases, offering distinct advantages over conventional treatments. This review explores the evolving landscape of tumor immunotherapy in the context of brain metastatic cancer, focusing on the intricate interplay between the tumor microenvironment (TME) and immunotherapeutic approaches. By elucidating the complex interactions within the TME, including the role of immune cells, cytokines, and extracellular matrix components, this review highlights the potential of immunotherapy to reshape the treatment paradigm for brain metastases.
Leveraging immune checkpoint inhibitors, cellular immunotherapies, and personalized treatment strategies, immunotherapy holds promise in overcoming the challenges posed by the blood-brain barrier and immunosuppressive microenvironment of brain metastases. Through a comprehensive analysis of current research findings and future directions, this review underscores the transformative impact of immunotherapy on the management of brain metastatic cancer, offering new insights and opportunities for personalized and precise therapeutic interventions.
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