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当前癌症免疫治疗的趋势和创新方法

英文原题:Current Trends and Innovative Approaches in Cancer Immunotherapy.

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Current Trends and Innovative Approaches in Cancer Immunotherapy.

PubMed 2024/07/24(内容时间) AAPS PharmSciTech Q1 · IF 5.1(JCR 2025)

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中文摘要

免疫治疗是癌症治疗领域最有前景的治疗方法之一。随着肿瘤的进展,肿瘤细胞利用一系列免疫调节机制来抑制肿瘤微环境中的免疫反应。利用我们对这些机制的理解,癌症免疫治疗已被开发出来,以增强免疫系统治疗癌症的有效性。目前有许多癌症免疫疗法已进入临床应用,但还有许多其他疗法要么处于不同的开发阶段,要么正在进行临床研究。在本文中,我们简要讨论癌症免疫疗法的特点和现状。这包括单克隆抗体、免疫检查点抑制剂、过继细胞疗法、细胞因子疗法、癌症疫苗和基因疗法的应用,所有这些在临床实践中都获得了显著认可。此外,我们还讨论了可能阻碍成功临床应用的局限性以及有前景的策略,例如将免疫疗法与纳米技术相结合。

展开英文摘要原文

Immunotherapy is one of the most promising therapeutic approaches in the field of cancer treatment. As a tumor progresses, tumor cells employ an array of immune-regulatory mechanisms to suppress immune responses within the tumor microenvironment. Using our understanding of these mechanisms, cancer immunotherapy has been developed to enhance the immune system's effectiveness in treating cancer.

Numerous cancer immunotherapies are currently in clinical use, yet many others are either in different stages of development or undergoing clinical studies. In this paper, we briefly discuss the features and current status of cancer immunotherapies. This includes the application of monoclonal antibodies, immune checkpoint inhibitors, adoptive cell therapy, cytokine therapy, cancer vaccines, and gene therapy, all of which have gained significant recognition in clinical practice.

Additionally, we discuss limitations that may hinder successful clinical utilization and promising strategies, such as combining immunotherapy with nanotechnology.

论文信息

作者
Kim J、Maharjan R、Park J
第一作者单位
Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 S. Limestone, Lexington, KY, 40506, USA.United States
通讯作者单位
Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 S. Limestone, Lexington, KY, 40506, USA. jonghyuck.park@uky.edu.United States
文献类型
综述
期刊
AAPS PharmSciTech2024 Jul 24
原文标识
PubMed 39044047 · DOI 10.1208/s12249-024-02883-x