体内 CAR 基因治疗的前景与潜在陷阱
Promises and potential pitfalls of in vivo CAR gene therapy.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
英文原题:Cancer biotherapy: review and prospect.
Cancer biotherapy: review and prospect.
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恶性肿瘤严重威胁人类生命质量, 我国恶性肿瘤患病率呈逐年上升趋势。目前临床治疗手段包括手术、放疗和药物治疗或联合治疗, 但均不能完全消灭恶性肿瘤细胞, 常出现转移和复发。而肿瘤生物治疗因其安全、有效、毒副作用小, 已成为防治恶性肿瘤的第四种有希望的模式。目前, 已有多种肿瘤生物治疗技术应用于临床, 包括基因治疗、肿瘤疫苗、单克隆抗体治疗、肿瘤干细胞治疗、细胞因子治疗、过继性细胞免疫治疗等。本研究就恶性肿瘤生物治疗的最新进展作一综述。
Malignant tumors pose a grave threat to the quality of human life. The prevalence of malignant tumors in China is steadily rising. Presently, clinical interventions encompass surgery, radiotherapy, and pharmaceutical therapy in isolation or combination. Nonetheless, these modalities fail to completely eradicate malignant tumor cells, frequently leading to metastasis and recurrence.
Conversely, tumor biotherapy has emerged as an encouraging fourth approach in preventing and managing malignant tumors owing to its safety, efficacy, and minimal adverse effects. Currently, a range of tumor biotherapy techniques are employed, including gene therapy, tumor vaccines, monoclonal antibody therapy, cancer stem cell therapy, cytokine therapy, and adoptive cellular immunotherapy.
This study aims to comprehensively review the latest developments in biological treatments for malignant tumors.
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