放疗驱动的肿瘤微环境免疫调节及其对临床结局的影响：一种有前景的新治疗范式

Traditional treatment approaches for advanced malignancies have been associated with limited clinical outcomes necessitating the development of novel therapies.

However, the ability of radiotherapy to induce pro-immunogenic changes in tumor immune microenvironment can be leveraged when combined with systemic agents. Radio-immunotherapeutic initiatives employing the use of monoclonal antibodies, genetically engineered T cells, cytokines and virus-vector mediated gene therapies have demonstrated promising potential for the management of various solid malignancies.

Future studies incorporating biomarker enrichment strategies and radiobiological variables could pave the way for immune-oncology based personalized medicine approaches to be integrated in standard of care practices for the treatment of challenging clinical populations.