基于器官囊过滤的胰腺靶向脂质纳米颗粒

Pancreatic-targeted lipid nanoparticles based on organ capsule filtration.

T 细胞中 STING 缺失是 STING 激动剂在胰腺癌 CAR-T 细胞免疫治疗中发挥疗效的必要条件

STING Ablation in T Cells Is Required for the Efficacy of STING Agonists in CAR-T Cell Immunotherapy of Pancreatic Cancer.

我们的研究结果提示，STING 缺陷的 CAR-T 细胞有望从 STING 激动剂中获益，以改善对胰腺癌等免疫匮乏型癌症的 CAR-T 细胞治疗。

CAR-T 细胞中双受体敲除阻断前列腺素 E(2) 信号增强实体瘤治疗疗效

Ablation of prostaglandin E(2) signalling through dual receptor knockout in CAR T cells enhances therapeutic efficacy in solid tumours.

CAR-巨噬细胞疗法：胰腺癌治疗希望的新时代

CAR-Macrophage Cell Therapy: A New Era of Hope for Pancreatic Cancer.

PDAC 中的 CRISPR/Cas9 基因组工程：从临床前研究到转化与临床研究

CRISPR/Cas9 genome engineering in PDAC: From preclinical studies to translation and clinical research.

靶向 γ-分泌酶复合物调控高侵袭性恶性肿瘤中的致癌 NOTCH 信号：一项系统综述

Modulation of Oncogenic NOTCH Signaling in Highly Aggressive Malignancies by Targeting the γ-Secretase Complex: A Systematic Review.

胰腺癌中肿瘤细胞对 CAR-T 细胞疗法耐药性的系统性探究

Systematic Interrogation of Tumor Cell Resistance to Chimeric Antigen Receptor T-cell Therapy in Pancreatic Cancer.

CAR-T 细胞中利用 microRNA 介导基因沉默的多重工程改造

Multiplex engineering using microRNA-mediated gene silencing in CAR T cells.

通过靶向 miRNA 实现的可滴定多重基因沉默为 CAR-T 细胞提供了基因编辑之外的替代方案，在效力、持久性、转移预防和免疫逃逸方面对异体产品具有潜在优势。

肿瘤中的 CAR-T 细胞治疗：批判性综述

Chimeric Antigen Receptor T-cell Therapy in Cancer: A Critical Review.