RNF43 p.G659fs 通过 PI3K/AKT/mTOR 信号通路和 HLA-E 上调导致 MSI-high 结直肠癌中 NK 细胞功能障碍
RNF43 p.G659fs leads to natural killer cell dysfunction in MSI-high colorectal cancer through PI3K/AKT/mTOR signaling and HLA-E up-regulation.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
间充质干细胞来源外泌体 microRNA 在结直肠癌中的双刃剑特性
英文原题：The Double-Edged Sword Property of Mesenchymal Stem Cell-Derived Exosomal microRNAs in Colorectal Cancer.
查看英文原题
The Double-Edged Sword Property of Mesenchymal Stem Cell-Derived Exosomal microRNAs in Colorectal Cancer.
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中文摘要
间充质干细胞（MSC）疗法因具有强效免疫调节和组织再生能力，是有前景的癌症治疗策略。在结直肠癌（CRC）中，MSC 具有双刃剑作用。一些报告指出，MSC 可抑制癌细胞增殖、迁移和浸润，从而抑制 CRC 的起始和发展；另一些报告则显示 MSC 会促进 CRC 进展。近期研究表明，MSC 来源外泌体 microRNA（MSC-Exo-miR）可能导致这种相互矛盾的作用。因此，本综述旨在探讨 MSC-Exo-miR 在 CRC 进展中的作用及其治疗 CRC 的潜力。
展开英文摘要原文
Mesenchymal stem cells (MSCs)-based therapies are promising therapeutic strategies for cancer treatment, because of their strong immunomodulatory and tissue regeneration abilities. In case of colorectal cancer (CRC), MSCs indicate a double-edged sword activity.
Some reports declared the inhibitory effects of MSCs on the proliferation, migration, and infiltration of cancer cells to suppress the CRC initiation and development, whereas others showed the tumor-promoter impacts of MSCs on the progression of CRC. Recent investigations have revealed that exosomal microRNAs (Exo-miRs) derived from MSCs (MSCs-Exo-miRs) are attributed to such paradoxical effect.
Thus, the current review aimed to seek the role of MSCs-Exo-miRs in CRC progression and their therapeutic potential for the CRC treatment.
论文信息
- 作者
- Yao H、Sun C、Wang C、Liu J、Li Y、Li L、Zhao B、Liu J
- 单位
- The Second Department of General Surgery, Hengshui People's Hospital, Hengshui, Hebei Province, China.China
- 文献类型
- 综述
- 期刊
- The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology2024 Aug 5
- 原文标识
- PubMed 39412096 · DOI 10.5152/tjg.2024.23541
在 PubMed 查看 → 出版商原文（DOI） 全文 PDF（PMC）· 可下载 治疗专题与资料阅读指南 资料来源与翻译说明 报告译文或资料问题 →