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中性粒细胞与淋巴细胞比值作为非小细胞肺癌肿瘤免疫状态指标的效用

英文原题：Utility of neutrophil-to-lymphocyte ratio as an indicator of tumor immune status in non-small cell lung cancer.

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Utility of neutrophil-to-lymphocyte ratio as an indicator of tumor immune status in non-small cell lung cancer.

PubMed 2024/08/14（内容时间） Jpn J Clin Oncol Q3 · IF 2.5（JCR 2025）

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非小细胞肺癌地区：日本
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研究概要

NLR 可能反映肿瘤微环境的免疫状态，从而解释其对 NSCLC 患者预后的影响。

中文摘要

背景

中性粒细胞/淋巴细胞比值（NLR）已被报道为非小细胞肺癌（NSCLC）的预后生物标志物，但其潜在生物学依据尚不清楚。本研究旨在探索 NLR 作为癌症免疫应答替代标志物的潜在用途并阐明其机制。

方法

本回顾性研究纳入 2012 年在研究机构接受手术的 120 例 NSCLC 患者病历。术前 30 天内通过血液检查确定外周血 NLR。采用免疫组化检测 CD3+、CD8+ 和 FOXP3+ TIL（肿瘤浸润淋巴细胞）以评估肿瘤免疫状态，并研究 NLR 与临床病理特征（包括 5 年总生存期〔OS〕）及肿瘤免疫状态的关系。NLR 和 TIL 计数中位数用作截点。

结果

低 NLR（<2.2）患者的 5 年 OS 显著优于高 NLR（≥2.2）患者（70.1% 对 56.8%，P=0.042）；CD3+ TIL 计数高（≥242）者也显著优于计数低（<242）者（70% 对 56.8%，P=0.019）。此外，CD3+ TIL 计数与术前 NLR 呈负相关（P=0.005）。

结论

NLR 可能反映肿瘤微环境免疫状态，从而解释其对 NSCLC 患者预后的影响。

展开英文摘要原文
BACKGROUND

Neutrophil-to-lymphocyte ratio (NLR) has been reported as a prognostic biomarker in non-small cell lung cancer (NSCLC); however, the underlying biological rationale remains unclear. The present study aimed to explore the potential utility of NLR as a surrogate biomarker for immune response to cancer and to elucidate the underlying mechanism.

METHODS

This retrospective study included the medical records of 120 patients with NSCLC who underwent surgery at the study institution in 2012. NLR in peripheral blood was determined from blood test within 30 days before surgery. Tumor immune status was evaluated using immunohistochemical staining to identify CD3+, CD8+ and FOXP3+ tumor-infiltrating lymphocytes (TILs), and the relationship of NLR, with clinicopathologic characteristics including 5-year overall survival (OS), and the tumor immune status was investigated. The median values of NLR and TIL count were used as cutoff points.

RESULTS

The 5-year OS was significantly better in patients with low NLR (<2.2) than in those with high NLR ( 2.2) (70.1% vs. 56.8%, P = 0.042) and in patients with high CD3+ TIL count ( 242) than in those with low CD3+ TIL count (<242) (70% vs. 56.8%, P = 0.019). Additionally, the CD3+ TIL count was negatively correlated with preoperative NLR (P = 0.005).

CONCLUSION

NLR might potentially reflect the immune status of tumor microenvironment, explaining its impact on prognosis of patients with NSCLC.

论文信息

作者
Iwata K、Suzawa K、Hashimoto K、Tanaka S、Shien K、Miyoshi K、Yamamoto H、Okazaki M
单位
Department of General Thoracic Surgery and Brest and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558, Japan.Japan
期刊
Japanese journal of clinical oncology2024 Aug 14
原文标识
PubMed 38704243　·　DOI 10.1093/jjco/hyae058

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