RNF43 p.G659fs 通过 PI3K/AKT/mTOR 信号通路和 HLA-E 上调导致 MSI-high 结直肠癌中 NK 细胞功能障碍
RNF43 p.G659fs leads to natural killer cell dysfunction in MSI-high colorectal cancer through PI3K/AKT/mTOR signaling and HLA-E up-regulation.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
基质 PD-L1 表达在结直肠癌肝转移中的作用
英文原题：Role of stromal PD-L1 expression in colorectal liver metastasis.
查看英文原题
Role of stromal PD-L1 expression in colorectal liver metastasis.
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研究概要
基质 PD-L1 表达可能是 CRLM 的重要预后标志物。
中文摘要
背景与目的
免疫检查点阻断治疗结直肠癌（CRC）的效果不理想，而且对多种癌症肝转移的疗效也较差。本研究探讨结直肠癌肝转移（CRLM）间质程序性死亡配体1（PD-L1）表达与患者预后的关系。
方法
研究纳入84例接受CRC根治性（R0）手术的CRLM患者，并通过免疫组化分析CRLM间质PD-L1表达。
结果
52.3%的CRLM样本表达间质PD-L1；其表达与最佳可切除转移灶较少相关（p=0.04），并有与较低肿瘤分级相关的趋势（p=0.08）。间质PD-L1阳性患者总生存期更长（p=0.003）。多变量分析显示，间质PD-L1表达（p=0.008）和较差分化程度（p<0.001）是独立预后指标。此外，间质PD-L1表达与较高TIL（肿瘤浸润淋巴细胞）数量相关。间质PD-L1阴性且TIL较低组的总生存率低于间质PD-L1阳性且TIL较高组（46.6%比81.8%，p=0.05）。间质PD-L1阳性患者无病生存期（DFS）更长（p=0.03），手术失败时间也更长（p=0.001）。有趣的是，间质PD-L1表达与硬化型组织学生长模式呈正相关（p=0.0002），与替代型模式呈负相关（p=0.008）。
结论
间质PD-L1表达可能是CRLM的重要预后标志物。
展开英文摘要原文
METHODS
The present study enrolled 84 CRLM patients who underwent surgery (R0) for CRC. Immunohistochemistry was performed to analyze stromal PD-L1 expression in CRLM.
RESULTS
Stromal PD-L1 was expressed in 52.3% of CRLM samples, which was associated with fewer not optimally resectable metastases (p = 0.04). Stromal PD-L1 also tended to associate with a lower tumor grade (p = 0.08). Stromal PD-L1-positive patients had longer overall survival (p = 0.003). Multivariate analysis identified stromal PD-L1 expression (p = 0.008) and poorer differentiation (p < 0.001) as independent prognostic indicators. Furthermore, stromal PD-L1 expression was correlated to a high number of tumor-infiltrating lymphocytes (TILs). Stromal PD-L1- and low TIL groups had shorter OS than stromal PD-L1 + and high TIL groups (46.6% vs. 81.8%, p = 0.05) Stromal PD-L1-positive patients had longer disease-free survival (DFS) (p = 0.03) and time to surgical failure (p = 0.001). Interestingly, stromal PD-L1 expression was positively related to the desmoplastic subtype (p = 0.0002) and inversely related to the replacement subtype of the histological growth pattern (p = 0.008).
CONCLUSIONS
Stromal PD-L1 expression may be a significant prognostic marker for CRLM.
论文信息
- 作者
- Takasu C、Morine Y、Yoshikawa K、Nakao T、Tokunaga T、Nishi M、Kashihara H、Wada Y
- 单位
- Department of Surgery, Tokushima University, Tokushima, Japan. takasu.chie@tokushima-u.ac.jp.Japan
- 期刊
- BMC cancer2024 Jan 17
- 原文标识
- PubMed 38233811 · DOI 10.1186/s12885-024-11869-8
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