基于 DNA 超分子水凝胶的保护性 NK 细胞储库用于增强三阴性乳腺癌治疗
Protective NK Cell Reservoir Based on DNA Supramolecular Hydrogel for Enhanced Triple-Negative Breast Cancer Therapy.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
新辅助化疗疗效的预测因素：三阴性乳腺癌中的炎症与免疫标志物
英文原题：Predictive factors for response to neoadjuvant chemotherapy: inflammatory and immune markers in triple-negative breast cancer.
查看英文原题
Predictive factors for response to neoadjuvant chemotherapy: inflammatory and immune markers in triple-negative breast cancer.
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研究概要
TILs、NLR 和 PLR 可预测 NAC 对三阴性乳腺癌的疗效。
中文摘要
背景
TIL（肿瘤浸润淋巴细胞）可预测三阴性乳腺癌（TNBC）患者对新辅助化疗（NAC）的应答，但只有少数机构能够测定TIL水平。相比之下，中性粒细胞与淋巴细胞比值（NLR）和血小板与淋巴细胞比值（PLR）可根据全血细胞计数结果方便、客观地测定。本回顾性研究评估TIL、NLR和PLR能否预测NAC疗效，以及NLR和PLR能否作为TNBC中TIL的替代指标。
方法
2013至2019年确诊的266例TNBC患者中，纳入66例接受蒽环类药物和紫杉烷序贯新辅助化疗后进行根治性手术的患者。依据受试者工作特征曲线确定截断值，并以TIL、NLR和PLR预测病理完全缓解（pCR）。
结果
TIL、NLR和PLR的截断值分别为20%、2.6和180。TIL水平较高与NLR较低（P=0.01）及PLR较低（P=0.01）相关。高TIL（OR 4.28，95% CI 1.40–13.1；P=0.01）、低NLR（OR 5.51，95% CI 1.60–18.9；P=0.01）和低PLR（OR 3.29，95% CI 1.13–9.57；P=0.03）均与pCR相关。低NLR可独立预测pCR（OR 6.59，95% CI 1.45–30.0；P=0.01）。
结论
TIL、NLR和PLR均可预测NAC治疗TNBC的疗效，且TIL水平与NLR、PLR相关。NLR是独立预测因素，在预测pCR时可能成为TIL的有用替代标志物。
展开英文摘要原文
BACKGROUND
Tumor-infiltrating lymphocytes (TILs) predict response to neoadjuvant chemotherapy (NAC) in triple-negative breast cancer (TNBC) patients. However, the TIL level can be determined at a few facilities. By contrast, neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are easily and objectively determined from the results of full blood counts. We conducted a retrospective study to investigate whether TILs, NLR, and PLR predict NAC efficacy and whether NLR and PLR could be surrogate markers for TILs in TNBC.
METHODS
Of the 266 patients diagnosed with TNBC between 2013 and 2019, 66 who underwent radical surgery after sequential administration of anthracycline and taxane as NAC were included in the study. TILs, NLR, and PLR were evaluated as predictors of pathologic complete response (pCR) using cutoff values determined from receiver operating characteristic curves.
RESULTS
The cutoff values of TILs, NLR, and PLR were 20%, 2.6, and 180, respectively. High TIL level was associated with low NLR (P = 0.01) and low PLR (P = 0.01). High TIL level (odds ratio [OR] 4.28 [95% CI 1.40-13.1]; P = 0.01), low NLR (OR 5.51 [95% CI 1.60-18.9]; P = 0.01), and low PLR (OR 3.29 [95% CI 1.13-9.57]; P = 0.03) were associated with pCR. Low NLR predicted pCR independently (OR 6.59 [95% CI 1.45-30.0]; P = 0.01).
CONCLUSIONS
TILs, NLR, and PLR predicted NAC efficacy against TNBC. TIL level was associated with NLR and PLR. NLR was an independent predictive factor and may be a useful surrogate marker for TILs when predicting pCR.
论文信息
- 作者
- Kusama H、Kittaka N、Soma A、Taniguchi A、Kanaoka H、Nakajima S、Oyama Y、Seto Y
- 第一作者单位
- Department of Breast and Endocrine Surgery, Osaka International Cancer Institute, 3-1-69 Otemae Chuo-Ku, Osaka, 541-8567, Japan.Japan
- 通讯作者单位
- Department of Breast and Endocrine Surgery, Osaka International Cancer Institute, 3-1-69 Otemae Chuo-Ku, Osaka, 541-8567, Japan. taqnakayama@hotmail.com.Japan
- 期刊
- Breast cancer (Tokyo, Japan)2023 Nov
- 原文标识
- PubMed 37782377 · DOI 10.1007/s12282-023-01504-y