一种用于克服非小细胞肺癌治疗中抗原异质性的多靶向 CAR-T 细胞平台
A Multi-Targeting Chimeric Antigen Receptor-T Cell Platform to Overcome Antigen Heterogeneity in the Treatment of Non-Small Cell Lung Cancer.
这些发现支持采用多靶点CAR-T 策略来应对NSCLC及可能其他实体瘤中的抗原异质性。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
小体积肺腺癌中实性成分占比与 TIL（肿瘤浸润淋巴细胞）的关系
英文原题：Relationship between consolidation tumor ratio and tumor-infiltrating lymphocytes in small-sized lung adenocarcinoma.
查看英文原题
Relationship between consolidation tumor ratio and tumor-infiltrating lymphocytes in small-sized lung adenocarcinoma.
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研究概要
在 GGO 组中，CTR 与 CD8+ 和 FoxP3+ TILs 的丰度相关。
中文摘要
背景
实性肿瘤比例（CTR）与肺腺癌（LAD）进展和组织学侵袭性相关，但小体积LAD中CTR与免疫相关因素（包括TIL（肿瘤浸润淋巴细胞）[TIL]密度、肿瘤程序性死亡配体1[PD-L1]及吲哚胺2,3-双加氧酶1[IDO1]表达）的关系尚不清楚。
方法
本研究纳入258名接受手术、肿瘤小于3厘米的LAD患者。患者分为四组：CTR=0；0<CTR<0.5；0.5≤CTR<1（磨玻璃影[GGO]组）；CTR=1（纯实性组）。采用免疫组化评估CD4+、CD8+和FoxP3+ TIL密度，以及PD-L1和IDO1肿瘤表达。
结果
在GGO组中，CD8+和FoxP3+ TIL密度随CTR增加而显著升高（均P<0.001）。此外，纯实性组PD-L1和IDO1表达显著高于GGO组（均P<0.001）。
结论
GGO组CTR与CD8+和FoxP3+ TIL丰度相关。纯实性组PD-L1和IDO1阳性率显著高于GGO组。CTR增加可能与免疫抑制状态相关。
展开英文摘要原文
BACKGROUND
Consolidation tumor ratio (CTR) is associated with cancer progression and histological invasiveness in lung adenocarcinoma (LAD). However, little is known about the association between CTR and immune-related factors, including tumor-infiltrating lymphocytes (TILs) density or tumor expression of programmed death ligand 1 (PD-L1) and indoleamine 2,3-dioxygenase 1 (IDO1) in small-sized LAD.
METHODS
This study included 258 patients with LAD (<3 cm) who underwent surgery. Patients were assigned to four groups: CTR = 0; 0 < CTR <0.5; 0.5 CTR <1 (ground-glass opacity [GGO] group); and CTR = 1 (pure-solid group). CD4 + , CD8 + , and FoxP3 + TIL density and PD-L1 and IDO1 tumor expression were assessed by immunohistochemistry.
RESULTS
Among the GGO group, CD8 + and FoxP3 + TIL density increased significantly with increasing CTR (p < 0.001 and p < 0.001, respectively). Moreover, PD-L1 and IDO1 expression was significantly higher in the pure-solid group than in the GGO group (p < 0.001 and p < 0.001, respectively).
CONCLUSIONS
CTR was correlated with the abundance of CD8 + and FoxP3 + TILs in the GGO group. PD-L1 and IDO1 positivity rates were significantly higher in the pure-solid group than in the GGO group. Increased CTR may be correlated with immunosuppressive condition.
论文信息
- 作者
- Ono Y、Tagawa T、Kinoshita F、Haratake N、Takada K、Kohno M、Takenaka T、Kamitani T
- 单位
- Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.Japan
- 期刊
- Thoracic cancer2022 Aug
- 原文标识
- PubMed 35791738 · DOI 10.1111/1759-7714.14524
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