基于 DNA 超分子水凝胶的保护性 NK 细胞储库用于增强三阴性乳腺癌治疗
Protective NK Cell Reservoir Based on DNA Supramolecular Hydrogel for Enhanced Triple-Negative Breast Cancer Therapy.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
乳腺癌新辅助化疗 (NAC) 后结局预测：基于肿瘤间质纤维化灶内 TIL（肿瘤浸润淋巴细胞）(FF-TILs)
英文原题：Outcome Prediction After Neoadjuvant Chemotherapy (NAC) for Breast Cancer, Using Tumor-infiltrating Lymphocytes Within Fibrotic Foci of Tumor Stroma (FF-TILs).
查看英文原题
Outcome Prediction After Neoadjuvant Chemotherapy (NAC) for Breast Cancer, Using Tumor-infiltrating Lymphocytes Within Fibrotic Foci of Tumor Stroma (FF-TILs).
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研究概要
FF-TILs 可能是预测乳腺癌 NAC 后复发的一个有用因素。
研究思路结论见上方概要
背景
TIL（肿瘤浸润淋巴细胞）（TILs）是免疫反应监测的指标，通常是与肿瘤聚集在一起的单核免疫细胞，被认为与癌细胞有密切关系。另一方面，肿瘤间质内的纤维化灶（FF）是一种组织学结构，在癌症微环境中对增殖和发展起重要作用。在此，我们聚焦于存在于FF内的TILs并进行了病理学评估。
方法
在接受新辅助化疗（NAC）治疗的320例患者中，239例能够评估FF-TILs的受试者被纳入目标人群。浸润FF的淋巴细胞即为FF-TILs。
结果
高FF-TIL组NAC后的无病生存期（DFS）在所有病例（p<0.001）以及三阴性乳腺癌（TNBC）（p=0.001）、人表皮生长因子受体2富集型乳腺癌（HER2BC）（p=0.010）和激素受体阳性乳腺癌（HRBC）（p=0.003）的所有亚型中均显著长于低FF-TIL组。在多变量分析中，高FF-TIL组分类同样是所有病例NAC后复发的独立因素[p<0.001，风险比（HR）=0.198]，以及TNBC（p=0.006，HR=0.172）、HER2BC（p=0.025，HR=0.135）和HRBC（p=0.007，HR=0.228）的所有亚型。
展开英文摘要原文
PATIENTS AND METHODS
Of the 320 patients treated with neoadjuvant chemotherapy (NAC), 239 subjects who were able to evaluate FF-TILs were targeted. Lymphocytes that infiltrate the FF are FF-TILs.
RESULTS
The disease-free survival (DFS) period after NAC for the high-FF-TIL group was found to be significantly longer than that for the low-FF-TIL group for all cases (p<0.001) and for all subtypes of triple-negative breast cancer (TNBC) (p=0.001), human epidermal growth factor receptor 2-enriched breast cancer (HER2BC) (p=0.010), and hormone receptor-positive breast cancer (HRBC) (p=0.003). In multivariable analysis as well, high-FF-TIL group classification was an independent factor for recurrence after NAC for all cases [p<0.001, hazard ratio (HR)=0.198] and all subtypes of TNBC (p=0.006, HR=0.172), HER2BC (p=0.025, HR=0.135), and HRBC (p=0.007, HR=0.228).
CONCLUSION
FF-TILs are possibly a useful factor for predicting recurrence of breast cancer after NAC.
论文信息
- 作者
- Kashiwagi S、Asano Y、Takada K、Goto W、Morisaki T、Shibutani M、Tanaka H、Hirakawa K
- 单位
- Department of Breast and Endocrine Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan; kashiwa@med.osaka-cu.ac.jp.Japan
- 期刊
- Anticancer research2022 Mar
- 原文标识
- PubMed 35220235 · DOI 10.21873/anticanres.15612