下一代基于抗体的癌症治疗:抗体-药物偶联物和双特异性抗体在血液系统恶性肿瘤和实体瘤中的应用
Next-generation antibody-based therapeutics in cancer: antibody-drug conjugates bispecific antibodies across hematologic malignancies and solid tumors
肿瘤学的治疗范式正在经历由抗体药物偶联物(ADC)和双特异性抗体(bsAb)驱动的深刻变革。
FRONTIER PAPERS
Next-generation antibody-based therapeutics in cancer: antibody-drug conjugates bispecific antibodies across hematologic malignancies and solid tumors
肿瘤学的治疗范式正在经历由抗体药物偶联物(ADC)和双特异性抗体(bsAb)驱动的深刻变革。
A spatially resolved implantable microdevice for multiplexed in situ screening of engineered cellular therapies in solid tumors.
实体瘤细胞免疫疗法的临床转化仍然受限,原因是缺乏足够的工具来评估原生肿瘤微环境中的治疗功能。
Quiescent tumor cells shape the immunosuppressive microenvironment in pancreatic cancer.
这些发现支持这样一个模型:罕见的静息肿瘤细胞通过EREG相关信号促进PDAC肿瘤微环境的重塑,并提示EREG抑制可能增强过继性细胞免疫治疗在该疾病中的疗效。
Next-generation precision oncology in microsatellite stable colorectal cancer: integrated targeting beyond RAS and RAF.
结直肠癌(CRC)的治疗格局随着分子亚型的识别而不断演变,这些亚型包括错配修复缺陷/微卫星高度不稳定、POLE突变、RAS/BRAF改变以及HER2扩增,使得精准治疗和免疫检查点抑制剂可用于特定人群。
B7 homolog 3-targeted CAR-T cells secreting EGFR T-cell engagers for improved control of glioblastoma progression.
我们的研究结果表明,用靶向 EGFR 的双特异性衔接器武装 B7-H3 CAR-T 细胞,是克服抗原异质性、改善 GBM 患者治疗结局的一种有前景的策略。
Next-generation therapeutics for glioblastoma: Challenges and future directions.
胶质母细胞瘤(GBM)是成人中最常见且最具侵袭性的原发性恶性脑肿瘤。
Current and Emerging Targeted Therapy in Advanced Gastroesophageal Adenocarcinoma.
背景/目的:晚期胃食管腺癌(GEA)预后较差,尽管采用标准化疗,中位总生存期仍为13-20个月。
An in vivo CRISPR screen unveils promising target genes to improve CAR-T cell efficacy in a solid tumor model.
这些结果表明,某些基因编辑策略可能对 CAR-T 细胞持久性产生有益、中性甚至有害的影响,具体取决于特定条件。
Injectable Hydrogels for Breast Cancer Therapy: From Tumor Microenvironment-Responsive and Actively Targeted Drug Delivery to Immunotherapy and Theran
乳腺癌治疗仍面临诸多挑战,包括局部复发、全身毒性、肿瘤异质性、耐药和免疫抑制。
Elevated interstitial fluid pressure promotes spheroid growth and reduces CAR-T therapeutic efficacy in solid tumors.
胰腺导管腺癌(PDAC)是最致命的实体瘤之一,其特征为侵袭性进展、致密的肿瘤微环境(TME)以及对常规治疗的耐药。
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