用代谢物感知受体工程化 NK 和 T 细胞以靶向实体瘤
Engineering NK and T cells with metabolite-sensing receptors to target solid tumors.
FRONTIER PAPERS
Engineering NK and T cells with metabolite-sensing receptors to target solid tumors.
Efficacy and safety of novel multiple-chain DAP-CAR-T cells targeting mesothelin in ovarian cancer and mesothelioma: a single-arm, open-label and firs
我们的研究突出了靶向 MSLN 的多链 DAP-CAR-T 细胞疗法治疗卵巢癌和间皮瘤患者的安全性和疗效。
Claudin-6 as a potential target in the treatment of ovarian cancer: a review of emerging drugs.
Claudin-6 靶向治疗为复发性或铂耐药卵巢癌患者代表了一种有前景的进展。在当前的方法中,ADC 由于其效力和可控的安全性特征,似乎最接近广泛的临床适用性。未来的成功将取决于标准化的诊断检测、生物标志物驱动的试验设计以及合理的联合策略,以克服耐药性并最大化持久的临床获益。
Signaling intact membrane-bound IL-15 enables potent anti-tumor activity and safety of CAR-NK cells.
头对头比较研究显示,与 sIL-15 相比,信号完整的 mbIL-15 显著提高了 CAR-NK 细胞的疗效和安全性,为未来临床开发提供了临床前证据。
The Role of Mesothelin in Gynecological Tumors and Its Significance in Targeted Therapies-A Review.
Different Immune Cells Modified With Chimeric Antigen Receptors Are Being Applied to Ovarian Cancer: Which Is the Most Effective?
Imaging CAR-NK cells targeted to HER2 ovarian cancer with human sodium-iodide symporter-based positron emission tomography.
Current Developments of CAR-T and CAR-NK Cell Therapies for Ovarian Cancer.
Novel applications of gene and cell therapies in the treatment of gynecological disorders.
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