用于乳腺癌治疗的可注射水凝胶:从肿瘤微环境响应性与主动靶向药物递送到免疫治疗与诊疗一体化
Injectable Hydrogels for Breast Cancer Therapy: From Tumor Microenvironment-Responsive and Actively Targeted Drug Delivery to Immunotherapy and Theran
乳腺癌治疗仍面临诸多挑战,包括局部复发、全身毒性、肿瘤异质性、耐药和免疫抑制。
FRONTIER PAPERS
Injectable Hydrogels for Breast Cancer Therapy: From Tumor Microenvironment-Responsive and Actively Targeted Drug Delivery to Immunotherapy and Theran
乳腺癌治疗仍面临诸多挑战,包括局部复发、全身毒性、肿瘤异质性、耐药和免疫抑制。
Antibody-Targeted Artificial T Cell and Natural Killer Cell Derived Vesicles for Cancer Immunotherapy.
T细胞和NK92细胞来源的细胞外囊泡或人工细胞衍生囊泡(ACDVs)通过继承的细胞毒性蛋白如穿孔素和颗粒酶或跨膜受体如FasL和TRAIL表现出抗癌效果。
Exploring the Potential of Receptor Silencing in the Tumor Microenvironment by RNA Interference.
较常采用的传统治疗方法存在副作用和耐药性问题。
A CAR T-inspiring platform based on antibody-engineered exosomes from antigen-feeding dendritic cells for precise solid tumor therapy.
CAR-T(CAR T)细胞疗法在临床研究中治疗血液系统恶性肿瘤患者已取得显著成果。
Combined Role of Interleukin-15 Stimulated Natural Killer Cell-Derived Extracellular Vesicles and Carboplatin in Osimertinib-Resistant H1975 Lung Canc
我们的研究结果首次表明,NK-EVs靶向PD-L1/PD-1免疫检查点,通过下调SOD2、PARP、BCL2、SET、NF-κB和TGF-ß来诱导凋亡和抗炎反应。
Surface-Engineered Natural Killer Cell-Derived Small Extracellular Vesicles Induce Potent Anti-Tumour Effects in Lung Cancer Cells.
我们的结果表明,装载 IL15 和西妥昔单抗的基因工程 NK-sEV 具有强效抗肿瘤活性和肿瘤靶向能力。
EGFR-Mutant Lung Adenocarcinoma Cell-Derived Exosomal miR-651-5p Induces CD8+ T Cell Apoptosis via Downregulating BCL2 Expression.
背景:程序性细胞死亡1(PD-1)或配体1(PD-L1)抑制剂在表皮生长因子受体(EGFR)突变非小细胞肺癌(NSCLC)患者中的疗效并不理想。
Radiation-Induced Tumor-Derived Extracellular Vesicles Combined with Tyrosine Kinase Inhibitors: An Effective and Safe Therapeutic Approach for Lung A
研究表明,高剂量分次放射产生的TEXs能够促使DC成熟,并增强细胞毒性T淋巴细胞的杀伤能力。
Recent Advances of Nanotechnology in the Diagnosis and Therapy of Triple- Negative Breast Cancer (TNBC).
通过利用几种生物标志物可以提高生存率。这些先进方法在triplenegative乳腺癌的预后和诊疗中也可能具有显著价值。与化疗、手术等相比,基于纳米技术的治疗方法最大的成功之一是显著降低了全身毒性,同时具有较高的治疗有效性。这些纳米载体可以满足快速诊断、更长循环时间、高效率和高效力等要求。
Colorectal Cancer: Risk Factors, Novel Approaches in Molecular Screening and Treatment.
到 2040 年,结直肠癌的疾病负担将增至每年 320 万新发病例和每年 160 万死亡病例。
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