肿瘤细胞治疗研究
英文原题：Recent Advances of Nanotechnology in the Diagnosis and Therapy of Triple- Negative Breast Cancer (TNBC).
通过利用几种生物标志物可以提高生存率。这些先进方法在triplenegative乳腺癌的预后和诊疗中也可能具有显著价值。与化疗、手术等相比，基于纳米技术的治疗方法最大的成功之一是显著降低了全身毒性，同时具有较高的治疗有效性。这些纳米载体可以满足快速诊断、更长循环时间、高效率和高效力等要求。
三阴性乳腺癌（TNBC）的先进治疗方法的开发是当今时代的迫切需求。TNBC被认为是侵袭性最强、最易转移的癌症，也是全球女性死亡的主要原因。缺乏雌激素、孕激素和人表皮受体2这三种受体的表达，即定义为TNBC。
本综述介绍了新型生物标志物，如miRNA及其家族、PD1、EGFR、VEGF、TILs、P53、AR和PI3K等，它们对TNBC的预后和诊断有显著贡献。一旦确诊，由于化疗的局限性，TNBC可采用先进的利用方法。新型方法包括脂质基（脂质体、SLN、NLC和SNEDDS）、聚合物基（胶束、纳米颗粒、树枝状聚合物和量子点）、先进纳米载体如（外泌体、抗体和肽-药物偶联物）以及碳基纳米载体（碳纳米管和氧化石墨烯）。脂质基递送因其作为疏水性药物的优良载体、生物相容性以及比化疗药物更低的全身毒性而被使用。聚合物基方法优于脂质，因为其能提供更长的循环时间、纳米尺寸、高负载效率、高连接性、避免药物外排、靶向作用、诊断和生物传感能力。先进方法如外泌体、偶联部分优于聚合物基，因为其具有效力、高渗透性、生物标志物以及避免组织毒性。碳基因其独特性质如多功能载体、预后、诊断、传感、光动力和光热特性而获得广泛适用性。
BACKGROUND: The development of advanced treatment of triple-negative breast cancer (TNBC) is the utmost need of an era. TNBC is recognized as the most aggressive, metastatic cancer and the leading cause of mortality in females worldwide. The lack of expression of triple receptors namely, estrogen, progesterone, and human epidermal receptor 2 defined TNBC. OBJECTIVE: The current review introduced the novel biomarkers such as miRNA and family, PD1, EGFR, VEGF, TILs, P53, AR and PI3K, etc. contributed significantly to the prognosis and diagnosis of TNBC. Once diagnosed, the advanced utilization approaches are available for TNBC because of the limitations of chemotherapy. Novel approaches include lipid-based (liposomes, SLN, NLC, and SNEDDS), polymer-based (micelle, nanoparticles, dendrimers, and quantum dots), advanced nanocarriers such as (exosomes, antibody and peptide-drug conjugates), and carbonbased nanocarriers (Carbon nanotubes, and graphene oxide). Lipid-based delivery is used for excellent carriers for hydrophobic drugs, biocompatibility, and lesser systemic toxicities than chemotherapeutic agents. Polymer-based approaches are preferred over lipids for providing longer circulation time, nanosize, high loading efficiency, high linking, avoiding the expulsion of drugs, targeted action, diagnostic and biosensing abilities. Advanced approaches like exosomes, conjugated moieties are preferred over polymeric for possessing potency, high penetrability, biomarkers, and avoiding the toxicity of tissues. Carbon-based gained wide applicability for their unique properties like a versatile carrier, prognostic, diagnostic, sensing, photodynamic, and photothermal characteristics. CONCLUSION: The survival rate can be increased by utilizing several kinds of biomarkers. The advanced approaches can also be significantly useful in the prognosis and theranostic of triplenegative breast cancer. One of the biggest successes in treating with nanotechnology-based approaches is the marked reduction of systemic toxicity with high therapeutic effectiveness compared with chemotherapy, surgery, etc. The requirements such as prompt diagnosis, longer circulation time, high efficiency, and high potency can be fulfilled with these nanocarriers.
MEMBER ACCOUNT
登录成功会直接打开下一页。
