免疫治疗新 ROR:通过单克隆抗体和 CAR NK 细胞靶向 ROR1 近端结构域治疗乳腺癌
A new immunotherapy ROR: Proximal ROR1 domain targeting breast cancer via monoclonal antibodies and CAR NK cells.
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A new immunotherapy ROR: Proximal ROR1 domain targeting breast cancer via monoclonal antibodies and CAR NK cells.
Development of a high-affinity anti-ROR1 variable region for broad anti-cancer immunotherapy.
受体酪氨酸激酶样孤儿受体1 (ROR1) 是肿瘤免疫治疗中一个新兴的靶点,因其在包括三阴性乳腺癌 (TNBC) 在内的多种上皮性肿瘤中持续且高表达而受到认可。
Erratum: Efficiently targeting neuroblastoma with the combination of anti-ROR1 CAR NK cells and N-803 in vitro and in vivo in NB xenografts.
[本文更正文章 DOI: 10.1016/j.omton.2024.200820。]
In vitro characterization of a novel anti-GD2/ROR1 bispecific antibody exhibiting tumor cell killing efficacy in neuroblastoma cross-cancer activity i
G/R-001 BsAb可同时结合GD2和ROR1,并在体外显示出显著的抗肿瘤活性。这些结果为G/R-001作为新型抗肿瘤治疗药物的进一步开发提供了有力的实验证据。
Combinatorial immunotherapy with anti-ROR1 CAR NK cells and an IL-21 secreting oncolytic virus against neuroblastoma.
我们的结果表明,分泌细胞因子的溶瘤病毒联合CAR-NK细胞是一种治疗高危NB的新型有效免疫治疗方法。
Immunotherapies for Breast Cancer: From Checkpoint Inhibition to Emerging Cellular Therapies.
乳腺癌仍是全球癌症相关发病率和死亡率的主要原因,其治疗反应受每种乳腺癌亚型独特生物学特征的影响。
Efficiently targeting neuroblastoma with the combination of anti-ROR1 CAR NK cells and N-803 in vitro and in vivo in NB xenografts.
在体内,与单用 anti-ROR1 CAR exPBNK 相比,anti-ROR1 CAR exPBNK 联合 N-803 显著(p < 0.05)提高了人 ROR1⁺ NB 异种移植 NSG 小鼠的生存率。
Whole Transcriptome Sequencing Reveals Cancer-Related, Prognostically Significant Transcripts and Tumor-Infiltrating Immunocytes in Mantle Cell Lympho
MCL肿瘤中致癌相关转录物的表达水平和/或微环境免疫细胞的比例可用于改善预后判断,从而实现更好的患者管理和治疗结果。
NKTR-255, a polymer-conjugated IL-15, synergizes with CAR-T cell therapy to activate endogenous anti-tumor immunity and improve tumor control.
我们的数据提示,将 NKTR-255 与 CAR-T 疗法联合,是增强 CAR-T 与内源性抗肿瘤免疫、从而促进对侵袭性肿瘤协同控制的一种有前景的策略。
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