CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
英文原题：Diagnostic Tissue Re-Evaluation Supporting the Observation of a (11)C-Methionine PET-Negative Residual Paraskeletal Mass in Multiple Myeloma.
Diagnostic Tissue Re-Evaluation Supporting the Observation of a (11)C-Methionine PET-Negative Residual Paraskeletal Mass in Multiple Myeloma.
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一名52岁男性Bence Jones蛋白型多发性骨髓瘤患者出现了巨大的骶骨相关、骨旁肿块。在接受放疗和idecabtagene vicleucel治疗后，血清和尿液免疫固定电泳检测均为阴性，骨髓微小残留病评估为阴性，治疗后11C-蛋氨酸正电子发射断层扫描/计算机断层扫描显示残留病灶无异常摄取，尽管计算机断层扫描显示肿块持续存在。在此病例中，重新活检在临床上并无必要。对诊断组织的重新评估显示浆细胞丰富区域和无细胞胶原丰富间质，伴有细胞外基质相关蛋白和轻链衍生肽。选择了观察，肿块逐渐缩小，无任何临床复发。
A 52-year-old man with Bence Jones protein -type multiple myeloma developed a large sacral bone-associated, paraskeletal mass. After radiotherapy and idecabtagene vicleucel, serum and urine immunofixation tests were negative, marrow minimal residual disease assessment was negative, and post-treatment 11 C-methionine positron emission tomography/computed tomography showed no abnormal uptake in the residual lesion, although computed tomography showed a persistent mass.
A re-biopsy was not clinically justified in this case. A re-evaluation of the diagnostic tissue revealed plasma cell-rich areas and acellular collagen-rich stroma with extracellular matrix-associated proteins and light chain-derived peptides. Observation was selected, and the mass gradually decreased without any clinical relapse.
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