基于 DNA 超分子水凝胶的保护性 NK 细胞储库用于增强三阴性乳腺癌治疗
Protective NK Cell Reservoir Based on DNA Supramolecular Hydrogel for Enhanced Triple-Negative Breast Cancer Therapy.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
三阴性乳腺癌的肿瘤微环境及利用冷冻消融和免疫刺激剂改善免疫治疗应答的策略
英文原题：The tumor microenvironment in triple negative breast cancer and a strategy to improve responses to immunotherapy using cryoablation and immunostimulants.
查看英文原题
The tumor microenvironment in triple negative breast cancer and a strategy to improve responses to immunotherapy using cryoablation and immunostimulants.
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中文摘要
每八名女性中就有一名在其一生中会罹患乳腺癌（BC）。三阴性乳腺癌（TNBC）占BC病例的20%，与其他BC亚型相比，其治疗选择较少、转移潜能更大、复发风险更高、预后更差。与激素受体阳性BC相比，TNBC具有更多的TIL（肿瘤浸润淋巴细胞）、更高的肿瘤突变负荷以及更强的程序性死亡配体-1（PD-L1）表达。尽管这些特征提示更强的免疫原性，但复杂的TNBC肿瘤微环境（TME）的平衡是免疫抑制性的。TME导致免疫检查点抑制剂（ICI）对TNBC的疗效有限且多变。本综述探讨了TNBC功能失调的免疫状态，并提出了一种多模式策略，将冷冻消融作为肿瘤相关抗原（TAA）的来源与免疫刺激剂相结合，以重编程抗肿瘤免疫。本综述特别探讨了将ICI和免疫刺激剂与作为TAA来源的冷冻消融相联合的策略。
展开英文摘要原文
One in eight women will develop breast cancer (BC) over their lifetime. Triple-negative breast cancer (TNBC) accounts for up to 20% of BC cases and has fewer treatment options, greater metastatic potential, a higher risk of recurrence, and a poorer prognosis compared to other BC subtypes. Compared to hormone receptor-positive BCs, TNBC has more tumor-infiltrating lymphocytes, a higher tumor mutational burden, and greater programmed death ligand-1 (PD-L1) expression.
While these features suggest greater immunogenicity, the balance of the complex TNBC tumor microenvironment (TME) is immunosuppressive. The TME leads to modest and variable effects of immune checkpoint inhibitors (ICI) for TNBC.
This review explores the dysfunctional immunological state of TNBC and proposes a multi-modal strategy integrating cryoablation as a source of tumor-associated antigens (TAAs) and immunostimulatory agents to reprogram antitumor immunity. It specifically explores the strategy of combining ICI and immunostimulants with cryoablation as a source of TAAs.
论文信息
- 作者
- Illindala R、Yang Y、Mandt T、Webster N、Steinmetz N、Newton I
- 单位
- Department of Radiology, University of California San Diego, La Jolla, United States.United States
- 文献类型
- 综述
- 期刊
- Cancer biology & therapy2026 Dec 31
- 原文标识
- PubMed 42247481 · DOI 10.1080/15384047.2026.2683942
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