CAR-T(CAR-T)细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CAR-T(CAR-T)细胞在血液系统恶性肿瘤中的应用推动了这种免疫治疗形式的显著进展。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
英文原题:Medical haematology: Repositioning haematology at the centre of medicine.
Medical haematology: Repositioning haematology at the centre of medicine.
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血液学正处于一个十字路口,分裂为血液肿瘤学与统称为“非恶性”血液学的若干不同学科。后一术语是一个误称,贬低了一系列复杂且危及生命的疾病,并导致劳动力短缺和研究不平等。本文主张正式采用“医学血液学”这一术语来重新定义这一领域。我们描绘了其在医学中的核心作用,从指导各专科的抗凝、输血和血栓护理到应对全球健康挑战。我们强调了其对分子医学和免疫疗法的开创性贡献,例如血友病的基因治疗以及CAR-T 细胞在自身免疫性疾病中的再利用。最后,我们提出了一个前瞻性蓝图,包括建立“血液团队”、改革教育课程和倡导公平,以确保该专业的未来。拥抱医学血液学是一项战略必然,以反映该专业内许多疾病的危及生命性质、吸引受训者、重新平衡研究重点,并牢固地重建血液学在现代医学实践核心中不可或缺的作用。
Haematology is at a crossroads, divided between haemato-oncology and the disparate disciplines collectively known as 'non-malignant' haematology. This latter term is a misnomer that devalues a spectrum of complex, life-threatening conditions and contributes to workforce shortages and research inequities. This article argues for the formal adoption of the term Medical Haematology to redefine this domain.
We chart its central role across medicine, from guiding anticoagulation, transfusion and thrombosis care across specialties to addressing global health challenges.
We highlight its pioneering contributions to molecular medicine and immunotherapy, exemplified by gene therapy for haemophilia and the repurposing of chimeric antigen receptor T cells for autoimmune disease.
Finally, we present a forward-looking blueprint involving establishment of 'Blood Teams', revamping educational curricula and championing equity to secure the speciality's future. Embracing Medical Haematology is a strategic imperative to reflect the life-threatening nature of many conditions within the speciality, attract trainees, rebalance research priorities and firmly re-establish haematology's indispensable role at the heart of modern medical practice.
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