TP53 缺失通过上调 NF-κB-IFN-β-MHC-Ia 信号促进骨肉瘤对 NK 细胞的抵抗
TP53 Loss Elevates NF-κB-IFN-β-MHC-Ia Signaling to Promote NK Cell Resistance in Osteosarcoma.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
间充质干细胞治疗皮肤辐射损伤
英文原题：Mesenchymal Stem Cell Treatment of Cutaneous Radiation Injury.
查看英文原题
Mesenchymal Stem Cell Treatment of Cutaneous Radiation Injury.
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中文摘要
再生医学是一个新兴的医学领域，专注于开发新型疗法以修复、替代或再生受损的细胞和组织。利用间充质干细胞（MSC）促进多种损伤和疾病状态下的组织修复，是再生医学中一个充满前景的方向。本文中，我们综述了MSC的基本干细胞生物学、其在治疗内脏放射损伤、皮肤损伤，特别是皮肤放射损伤中的应用。我们还重点介绍了已公开的临床病例报告，其中MSC被用于治疗急性皮肤放射损伤。同时探讨了不同来源MSC的效用、MSC与MSC产品的比较，以及各种MSC治疗方案。
展开英文摘要原文
Regenerative medicine is an emerging field of medicine focusing on the development of novel therapies to repair, replace, or regenerate damaged cells and tissues. Mesenchymal stem cell (MSC) use to promote tissue repair in a variety of injury and disease states is one promising area of regenerative medicine.
Herein, we review the fundamental stem cell biology of MSCs, their use in the treatment of radiation injury to internal organs, cutaneous injury, and specifically, cutaneous radiation injury.
We also highlight publicly available clinical case reports where MSCs have been used in the treatment of acute cutaneous radiation injury. The utility of differentially sourced MSCs, MSCs versus MSC products, and various MSC treatment plans are also explored.
论文信息
- 作者
- Sproull MT、Jackson LR、Citrin DE、Camphausen K
- 单位
- Radiation Oncology Branch, National Cancer Institute, Bethesda, Maryland. Electronic address: sproullm@mail.nih.gov.United States
- 文献类型
- 综述 · 美国 NIH 资助研究 · 非美国政府资助研究
- 期刊
- International journal of radiation oncology, biology, physics2026 Jul 1
- 原文标识
- PubMed 41418985 · DOI 10.1016/j.ijrobp.2025.12.008