RNF43 p.G659fs 通过 PI3K/AKT/mTOR 信号通路和 HLA-E 上调导致 MSI-high 结直肠癌中 NK 细胞功能障碍
RNF43 p.G659fs leads to natural killer cell dysfunction in MSI-high colorectal cancer through PI3K/AKT/mTOR signaling and HLA-E up-regulation.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
RTP4 通过 MHC-I 介导的 CD8(+) T 细胞浸润抑制结直肠癌进展并增强免疫治疗反应
英文原题：RTP4 Suppresses Colorectal Cancer Progression via MHC-I-Mediated CD8(+) T Cell Infiltration and Enhances Immunotherapy Response.
查看英文原题
RTP4 Suppresses Colorectal Cancer Progression via MHC-I-Mediated CD8(+) T Cell Infiltration and Enhances Immunotherapy Response.
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中文摘要
尽管已知 RTP4 可调控气味受体转运，但其在结直肠癌（CRC）中的作用仍不清楚。本研究探讨了 RTP4 在 CRC 中的临床相关性及功能机制。综合分析显示，RTP4 在 CRC 组织中表达显著下调，并与患者不良预后相关。RTP4 表达与免疫相关基因、生物学过程及抗肿瘤免疫细胞浸润密切相关。机制研究表明，RTP4 上调 MHC-I 表达，从而在细胞和动物模型中增强 CD8 + T 细胞募集并强化抗肿瘤免疫。此外，RTP4 过表达显著提高了免疫检查点阻断治疗的疗效。总而言之，我们的研究结果确立了 RTP4 作为预后预测的双功能生物标志物，以及增强 CRC 免疫治疗反应性的潜在靶点。
展开英文摘要原文
While RTP4 is known to regulate odorant receptor trafficking, its role in colorectal cancer (CRC) remains unclear.
This study investigates the clinical relevance and functional mechanisms of RTP4 in CRC. Comprehensive analyses revealed significant downregulation of RTP4 expression in CRC tissues, correlating with poor patient prognosis. RTP4 expression showed strong associations with immune-related genes, biological processes and anti-tumour immune cell infiltration. Mechanistic studies demonstrated that RTP4 upregulates MHC-I expression, which enhances CD8 + T cell recruitment and strengthens anti-tumour immunity in both cellular and animal models.
Furthermore, RTP4 overexpression markedly improved the efficacy of immune checkpoint blockade therapy. All in all, our findings establish RTP4 as a dual-functional biomarker for prognosis prediction and a potential target to enhance immunotherapy responsiveness in CRC.
论文信息
- 作者
- Yu C、Li Y、Liu Z、Ye W、Wei L、Xu W、Yan L、Ye H
- 第一作者单位
- Department of General Surgery, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.China
- 通讯作者单位
- Medical Center of Burn Plastic and Wound Repair, the First Affiliated Hospital, School of Basic Medical Sciences, Institute of Biomedical Innovation, Jiangxi Medical College, Nanchang University, Nanchang, China.China
- 文献类型
- 非美国政府资助研究
- 期刊
- Journal of cellular and molecular medicine2025 Oct
- 原文标识
- PubMed 41126439 · DOI 10.1111/jcmm.70915
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