RNF43 p.G659fs 通过 PI3K/AKT/mTOR 信号通路和 HLA-E 上调导致 MSI-high 结直肠癌中 NK 细胞功能障碍
RNF43 p.G659fs leads to natural killer cell dysfunction in MSI-high colorectal cancer through PI3K/AKT/mTOR signaling and HLA-E up-regulation.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
英文原题:Revolution of Traditional Chinese Medicine in Anticancer Therapy, Applications and Future Perspective.
Revolution of Traditional Chinese Medicine in Anticancer Therapy, Applications and Future Perspective.
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在中国,抗癌斗争已引起众多研究人员、科学家、药理学家和药物干预者的关注。癌症是全球主要死因,而中医药的探索在现代医学和肿瘤患者中发挥着积极作用。
文献检索在 PubMed、Web of Science、Scopus、PubChem、Google Scholar、SCI 及多种在线数据源中完成。本综述总结了中医药作为癌症辅助治疗的药理学和应用。
在中国,超过 75% 的癌症病例使用草药疗法和替代疗法如中医药进行治疗。研究人员关注抑制癌细胞生长、凋亡和转移的西方药物,并应用中医药治疗癌症患者。此外,中国用于癌症患者的补充和替代疗法,对接受化疗和放疗联合治疗的癌因性疲乏患者有帮助。 讨论:中医药对研究人员而言是一种有前景的策略,并为未来形成基于中医药的癌症治疗研究假说提供了坚实基础,这些治疗副作用更少并改善患者健康。
中医药抗癌进展调节免疫反应以及NK 细胞、T 细胞和 B 细胞、先天免疫、巨噬细胞和 CD4+ 淋巴细胞的作用。此外,中医药纳米治疗中的化学预防措施揭示了潜在癌症机制和抑癌基因,促进了中国癌症患者的生存。此外,它为传统中药在控制癌细胞生长、癌症干细胞、DNA甲基化、细胞凋亡以及提高患者依从性、促进健康方面的治疗效果提供了新的见解。
<p> Background: The battle against cancer has gained the interest of various researchers, scientists, pharmacologists, and pharmaceutical intervenors in China. Cancer is a leading cause of death worldwide, and the exploration of Traditional Chinese medicine plays an active role in modern medicine and patients with tumors. </p><p> Method: The literature search was done in PubMed, Web of Science, Scopus, PubChem, Google Scholar, SCI, and various online data sources.
The review summarizes the pharmacology and applications of TCM as an adjuvant cancer therapeutic. </p><p> Results: More than 75% of cancer cases are treated using herbal remedies and alternative therapies like TCM in China. Researchers have focused on Western medicines for inhibiting cancer cell growth, apoptosis, and metastasis, with applications of TCM medicines in cancer patients.
Furthermore, the complementary and alternative therapies used for cancer patients in China are helpful for cancer-fatigue patients with a combination of chemotherapy and radiotherapy.
</p><p> Discussion: TCM is a promising strategy for researchers and provides a solid foundation for formulating future hypotheses for studies on TCM-based cancer therapy with fewer side effects and improving patient health. </p><p> Conclusion: TCM anticancer progress regulates immune responses and the role of natural killer cells, T and B cells, innate immunity, macrophages, and CD4+ lymphocytes.
Additionally, chemopreventive measures in TCM nanotherapeutics shed light on underlying cancer mechanisms and cancer-suppressing genes, promoting the survival of cancer-affected patients in China.
Further, it provides newer insights into the therapeutic effects of traditional Chinese medicine in controlling cancer cell growth, cancer stem cells, DNA methylation, apoptosis, and improving patient compliance, promoting health.
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