单细胞追踪揭示黑色素瘤 TIL 治疗过程中肿瘤反应性 T 细胞的可塑性
Single-cell tracking reveals tumor-reactive T cell plasticity during melanoma TIL therapy.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
转移性病灶切除术在获取 TIL（肿瘤浸润淋巴细胞）用于采集及生物标志物/基因组检测中的作用
英文原题：Role of Metastasectomy for Tissue Acquisition for Tumor-Infiltrating Lymphocyte Harvest and Biomarker/Genomic Testing.
查看英文原题
Role of Metastasectomy for Tissue Acquisition for Tumor-Infiltrating Lymphocyte Harvest and Biomarker/Genomic Testing.
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中文摘要
TIL（肿瘤浸润淋巴细胞）疗法是一种新兴的治疗模式，在缺乏许多良好替代方案的患者群体中显示出有希望的早期结果。在某些无法获取原发肿瘤或软组织转移灶的情况下，胸外科医生可能可以发挥作用，从肺转移灶中获取组织。通常，这些可以是局限性切除，大多数病例适合楔形切除，因为通常只需要1 cm的组织。因此，在适当选择的患者中，已显示肺部、心血管、感染和伤口并发症的风险较低。
展开英文摘要原文
Tumor-infiltrating lymphocyte therapy is an emerging paradigm with promising early results for a patient population without many good alternatives. In some cases where the primary tumor or soft tissues metastases cannot be harvested, there may be a role for the thoracic surgeon to harvest tissue from pulmonary metastases.
Typically, these can be limited resections with most cases being amenable to a wedge resection as only 1 cm of tissue is usually required. As a result, in appropriately selected patients, there has been shown to be a low risk of pulmonary, cardiovascular, infectious, and wound complications.
论文信息
- 作者
- Huang K、Bostock IC
- 第一作者单位
- Department of Surgery, Medical University of South Carolina, 171 Ashley Avenue, Charleston, SC 29425, USA.United States
- 通讯作者单位
- Department of Thoracic Surgery, Miami Cancer Institute, Baptist Health South Florida, 8900 N Kendall Drive, Miami, FL 33176, USA. Electronic address: bostock.ian@gmail.com.United States
- 文献类型
- 综述
- 期刊
- Thoracic surgery clinics2025 May
- 原文标识
- PubMed 40246406 · DOI 10.1016/j.thorsurg.2024.11.010