RNF43 p.G659fs 通过 PI3K/AKT/mTOR 信号通路和 HLA-E 上调导致 MSI-high 结直肠癌中 NK 细胞功能障碍
RNF43 p.G659fs leads to natural killer cell dysfunction in MSI-high colorectal cancer through PI3K/AKT/mTOR signaling and HLA-E up-regulation.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
早期结肠癌新型病理标志物评估：启示与局限
英文原题：Assessment of new pathological markers in early stage colon cancer: Insights and limitations.
查看英文原题
Assessment of new pathological markers in early stage colon cancer: Insights and limitations.
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研究概要
未发现新病理标志物的存在与高危/低危分组之间存在关联。
中文摘要
背景
对局限期患者是否给予辅助化疗，取决于是否存在特定高危特征，包括 T4 肿瘤分期、神经周围侵犯、淋巴血管侵犯、组织学分化差、淋巴结取样不足（少于 12 枚），以及肿瘤穿孔或梗阻的证据。肿瘤-间质比、TIL（肿瘤浸润淋巴细胞）、克罗恩样反应（CLR）、硬纤维瘤样反应及低分化细胞簇（PDC）是正在研究的新型病理标志物。
目的
考察早期结直肠癌中这些新型病理标志物与已定义高危因素之间的关系。
方法
评估 2007 至 2021 年间在特拉基亚大学医院肿瘤内科接受治疗的 155 例 I 期或 II 期结直肠癌患者。依据有无高危因素将患者分为两组，并考察新型病理标志物与分组及高危因素中病理标志物的关联。
结果
TIL、PDC、肿瘤出芽、CLR 或硬纤维瘤样反应的存在与低危或高危组之间均无统计学显著相关性；对于 PDC 程度，所报告的 P 值依次为 0.82、0.51、0.77、0.37 和 0.83。此外，肿瘤-间质比与低危或高危组亦无显著相关性（P = 0.80）。PDC 的存在与 PDC 3 级以及 T 分期均显著相关（两者 P = 0.001）。随着 T 分期升高，PDC 的检出率及 3 级 PDC 的比例增加。
结论
未发现新型病理标志物的存在与高低危分组相关。比较新旧病理标志物时，仅 PDC 及 3 级 PDC 的检出频率与较晚 T 分期相关。
展开英文摘要原文
BACKGROUND
The decision to administer adjuvant chemotherapy to patients with local stage depends on specific high-risk features that are T4 tumor stage, presence of perineural invasion, lymphovascular invasion, poorly differentiated tumor histology, inadequate lymph node sampling (fewer than 12 lymph nodes), and evidence of tumor perforation or obstruction. Tumor-stroma ratio, tumor infiltrating lymphocytes (TIL), Crohn-like reaction (CLR), desmoid reaction, poorly differentiated clusters (PDC) are new pathological markers that are being studied. AIM: To examine the relationship between new pathological markers and defined high risk factors, in early stage colorectal cancer.
METHODS
We evaluated 155 patients with the diagnosis stage I and II colorectal cancer between the years 2007 and 2021 who were treated at Trakya University Hospital, Department of Medical Oncology. We divided those with and without high-risk factors into two groups. We examined the relationship of new pathological markers with these groups and with pathological markers in risk factors.
RESULTS
There was no statistically significant correlation between presence of TIL, presence of PDC, presence of tumor budding, presence of CLR, presence of desmoid reaction and low and high-risk groups according to the degree of those with PDC ( P = 0.82, P = 0.51, P = 0.77, P = 0.37, P = 0.83, respectively). In addition, no statistically significant correlation was found between the tumor-stroma ratio and low and high risk groups ( P = 0.80). We found a statistically significant correlation between the presence of PDC and the presence of PDC grade 3 and T stage ( P = 0.001, P = 0.001, respectively). It was determined that the presence of PDC and the frequency of grade 3 PDC increased with the advanced T stage.
CONCLUSION
No relationship was found between the presence of new pathological markers and high-low risk groups. When we examined the relationship between new and old pathological markers, only the frequency of detection of PDC and PDC grade 3 was found to be correlated with advanced T stage.
论文信息
- 作者
- Erdogan B、Usturalı Keskin FE、Özcan E、Küçükarda A、Güren AK、Köstek O、Hacioglu BM、Kodaz H
- 第一作者单位
- Department of Medical Oncology, Division of Medical Oncology, Department of Internal Medicine, Trakya University School of Medicine, Edirne 22000, Türkiye.
- 通讯作者单位
- Department of Medical Oncology, Acibadem Eskisehir Hospital, Eskisehir 26130, Türkiye. hilmikodaz@hotmail.com.
- 期刊
- World journal of gastrointestinal oncology2025 Mar 15
- 原文标识
- PubMed 40092924 · DOI 10.4251/wjgo.v17.i3.101325
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