基于 DNA 超分子水凝胶的保护性 NK 细胞储库用于增强三阴性乳腺癌治疗
Protective NK Cell Reservoir Based on DNA Supramolecular Hydrogel for Enhanced Triple-Negative Breast Cancer Therapy.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
英文原题:Current status of cytokine-induced killer cells and combination regimens in breast cancer.
Current status of cytokine-induced killer cells and combination regimens in breast cancer.
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乳腺癌仍然是全球重大的健康挑战,人们在理解其发病机制、生物学特征和临床诱因方面投入了大量努力。近年来,细胞因子诱导的杀伤细胞联合其他药物疗法等免疫治疗为晚期乳腺癌患者带来了新的希望。然而,涉及细胞因子诱导的杀伤细胞的联合方案的具体发病机制仍不明确。此外,细胞因子诱导的杀伤细胞免疫治疗的联合应用可能代表一种新的突破。本综述概述了细胞因子诱导的杀伤细胞疗法及其联合策略,特别是化疗联合分子靶向治疗,在乳腺癌管理中的现状。
Breast cancer remains a significant health challenge worldwide, with substantial efforts aimed at understanding its pathogenesis, biological characteristics, and clinical triggers. Recently, immunotherapy such as the cytokine-induced killer cells combined with other drug therapies has offered new hope for patients with advanced breast cancer.
However, the specific pathogenesis of combination regimens involving cytokine-induced killer cells remains elusive. Besides, the combination of immunotherapy with cytokine-induced killer cells might represent a novel breakthrough. This review outlines the current status of cytokine-induced killer cell therapies and their combination strategies, especially the combination of chemotherapy with molecularly targeted treatments, for the management of breast cancer.
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