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细胞因子诱导的杀伤细胞及其联合方案在乳腺癌中的现状

英文原题:Current status of cytokine-induced killer cells and combination regimens in breast cancer.

查看英文原题

Current status of cytokine-induced killer cells and combination regimens in breast cancer.

PubMed 2025/02/06(内容时间) Front Immunol Q1 · IF 7(JCR 2025)

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中文摘要

乳腺癌仍然是全球重大的健康挑战,人们在理解其发病机制、生物学特征和临床诱因方面投入了大量努力。近年来,细胞因子诱导的杀伤细胞联合其他药物疗法等免疫治疗为晚期乳腺癌患者带来了新的希望。然而,涉及细胞因子诱导的杀伤细胞的联合方案的具体发病机制仍不明确。此外,细胞因子诱导的杀伤细胞免疫治疗的联合应用可能代表一种新的突破。本综述概述了细胞因子诱导的杀伤细胞疗法及其联合策略,特别是化疗联合分子靶向治疗,在乳腺癌管理中的现状。

展开英文摘要原文

Breast cancer remains a significant health challenge worldwide, with substantial efforts aimed at understanding its pathogenesis, biological characteristics, and clinical triggers. Recently, immunotherapy such as the cytokine-induced killer cells combined with other drug therapies has offered new hope for patients with advanced breast cancer.

However, the specific pathogenesis of combination regimens involving cytokine-induced killer cells remains elusive. Besides, the combination of immunotherapy with cytokine-induced killer cells might represent a novel breakthrough. This review outlines the current status of cytokine-induced killer cell therapies and their combination strategies, especially the combination of chemotherapy with molecularly targeted treatments, for the management of breast cancer.

论文信息

作者
Jiang Y、Qiu J、Ye N、Xu Y
单位
Department of Breast and Thyroid Surgery, Shaoxing People's Hospital, Shaoxing, China.China
文献类型
综述
期刊
Frontiers in immunology2025
原文标识
PubMed 39981243 · DOI 10.3389/fimmu.2025.1476644