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同种异体策略释放 CAR-T 细胞在实体瘤中的获益

英文原题:Allogeneic approach unlocks CAR T cell benefits in solid tumors.

查看英文原题

Allogeneic approach unlocks CAR T cell benefits in solid tumors.

PubMed 2025/03/01(内容时间) Nat Med Q1 · IF 52.5(JCR 2025)

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中文摘要

一项规模较小但深入的研究显示,异体 CAR-T 细胞疗法用于高危神经母细胞瘤患者具有可行性并可能有效;机制研究还揭示了有望改善 CAR-T 细胞在实体瘤中功能的相关通路。

展开英文摘要原文

A small but in-depth study of allogeneic CAR T cell therapy in patients with high-risk neuroblastoma shows feasibility and potential efficacy, and mechanistic insights reveal pathways to improved functionality of CAR T cells in solid tumors.

论文信息

作者
Chok R、Ramakrishna S
第一作者单位
Division of Hematology, Oncology, Stem Cell Transplantation, and Regenerative Medicine, Department of Pediatrics, Stanford University School of Medicine, Palo Alto, CA, USA.United States
通讯作者单位
Division of Hematology, Oncology, Stem Cell Transplantation, and Regenerative Medicine, Department of Pediatrics, Stanford University School of Medicine, Palo Alto, CA, USA. ramakrs@stanford.edu.United States
期刊
Nature medicine2025 Mar
原文标识
PubMed 39920392 · DOI 10.1038/s41591-025-03510-3