RNF43 p.G659fs 通过 PI3K/AKT/mTOR 信号通路和 HLA-E 上调导致 MSI-high 结直肠癌中 NK 细胞功能障碍
RNF43 p.G659fs leads to natural killer cell dysfunction in MSI-high colorectal cancer through PI3K/AKT/mTOR signaling and HLA-E up-regulation.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
PCED1A 在肝细胞癌和结直肠癌中的表达及其与免疫浸润的关系：作为诊断标志物的潜力
英文原题：Expression of PCED1A in Hepatocellular Carcinoma and Colorectal Cancer and Its Relationship with Immune Infiltration: Potential as a Diagnostic Marker.
查看英文原题
Expression of PCED1A in Hepatocellular Carcinoma and Colorectal Cancer and Its Relationship with Immune Infiltration: Potential as a Diagnostic Marker.
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研究概要
PCED1A 与肿瘤免疫浸润相关，是 HCC 和 CRC 有前景的诊断生物标志物和有价值的治疗靶点。
研究思路结论见上方概要
背景
肝细胞癌（HCC）和结直肠癌（CRC）在全球范围内对人类健康构成重大威胁，其发病机制复杂。含PC-酯酶结构域1A（PCED1A）是GDSL/SGNH超家族的重要成员。
目的
本研究的目的是探讨PCED1A在HCC和CRC中的诊断价值及其与免疫浸润的关系。
方法
使用癌症基因组图谱（TCGA）数据库、基因表达综合（GEO）数据库、癌症细胞系百科全书数据库（CCLE）和人类蛋白质图谱（HPA）检测PCED1A在组织和细胞中的表达。使用Cibersoft、Timer和Xcell分析PCED1A对免疫细胞浸润的影响。分析PCED1A与免疫检查点之间的关系。使用LinkedOmics数据库对PCED1A进行共表达分析。
结果
PCED1A在预后不良的HCC和CRC中表达升高。免疫组化显示，与相应正常组织相比，PCED1A在HCC和CRC中高表达。PCED1A表达与较差的总生存期（OS）和无进展生存期（PFS）相关。PCED1A高表达与M2巨噬细胞强烈相关，影响HCC进展。相反，PCED1A低表达与CRC中的Th2细胞密切相关。此外，名为PDCD1的检查点在HCC和CRC中与PCED1A高表达组显示出良好的相关性。最后，通过对LinkedOmics数据库的共表达分析，PCED1A与ZNF家族之间显示出复杂而交织的关系。
展开英文摘要原文
BACKGROUND
Hepatocellular carcinoma (HCC) and colorectal cancer (CRC) pose a significant threat to human health worldwide, characterized by intricate pathogenesis. A PC-esterase domain containing 1A (PCED1A) is a critical number of the GDSL/SGNH superfamily. AIM: The aim of this study is to explore the diagnostic value of PCED1A in HCC and CRC and its relationship with immune infiltration.
METHODS
The Cancer Genome Atlas (TCGA) database, Gene Expression Omnibus (GEO) database, the Cancer Cell Line Encyclopedia database (CCLE), and the Human Protein Atlas (HPA) were used to detect the expression of PCED1A in tissues and cells. Cibersoft, Timer, and Xcell were used to analyze the effect of PCED1A on immune cell infiltration. The relationship between PCED1A and the immune checkpoint was analyzed. The coexpression analysis of PCED1A was conducted using the LinkedOmics database.
RESULTS
PCED1A was increased in HCC and CRC with poor prognosis. Immunohistochemistry demonstrated that PCED1A was highly expressed in HCC and CRC compared to corresponding normal tissues. PCED1A expression was related to poor overall survival (OS) and progression-free survival (PFS). High PCED1A expression was strongly associated with M2 macrophages, impacting HCC progression. Conversely, low PCED1A expression was closely related to Th2 cells in CRC. In addition, the checkpoint named PDCD1 showed a good correlation with PCED1A high expression group in HCC and CRC. Lastly, the PCED1A and ZNF family showed a complex and intertwined relationship through coexpression analysis on the LinkedOmics database.
CONCLUSION
PCED1A, related to tumor immune infiltration, is a promising diagnostic biomarker and a valuable therapeutic target for HCC and CRC.
论文信息
- 作者
- Wang M、Zhang Q、Wang J
- 单位
- Department of Gastroenterology, Songjiang Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.China
- 期刊
- Journal of gastroenterology and hepatology2025 Apr
- 原文标识
- PubMed 39865523 · DOI 10.1111/jgh.16890