CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
CAR-T 细胞治疗乳腺癌的现状与创新进展
英文原题：Current status and innovative developments of CAR-T-cell therapy for the treatment of breast cancer.
查看英文原题
Current status and innovative developments of CAR-T-cell therapy for the treatment of breast cancer.
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中文摘要
据预计，乳腺癌在2024年的诊断病例数将超过其他所有癌症。乳腺癌在女性癌症发病率和死亡率中均位居首位。由于当前临床药物导致的治疗耐药阻碍疗效，亟需创新治疗方法。以T细胞为基础的嵌合抗原受体（CAR）T细胞免疫疗法利用患者自身免疫细胞对抗癌症，在治疗血液系统恶性肿瘤方面疗效显著；然而，该疗法治疗乳腺癌等实体瘤的效果未达预期。本文详细讨论乳腺癌肿瘤相关抗原的作用、当前临床试验、CAR-T 细胞疗法达到预期疗效的障碍以及提高疗效的潜在途径。最后，本文综述乳腺癌CAR-T 细胞疗法的最新进展，希望激发读者进一步关注。
展开英文摘要原文
Breast cancer will overtake all other cancers in terms of diagnoses in 2024. Breast cancer counts highest among women in terms of cancer incidence and death rates. Innovative treatment approaches are desperately needed because treatment resistance brought on by current clinical drugs impedes therapeutic efficacy.
The T cell-based immunotherapy known as chimeric antigen receptor (CAR) T cell treatment, which uses the patient's immune cells to fight cancer, has demonstrated remarkable efficacy in treating hematologic malignancies; nevertheless, the treatment effects in solid tumors, like breast cancer, have not lived up to expectations.
We discuss in detail the role of tumor-associated antigens in breast cancer, current clinical trials, barriers to the intended therapeutic effects of CAR-T cell therapy, and potential ways to increase treatment efficacy.
Finally, our review aims to stimulate readers' curiosity by summarizing the most recent advancements in CAR-T cell therapy for breast cancer.
论文信息
- 作者
- Marei HE、Bedair K、Hasan A、Al-Mansoori L、Caratelli S、Sconocchia G、Gaiba A、Cenciarelli C
- 单位
- Department of Cytology and Histology, Faculty of Veterinary Medicine, Mansoura University, Mansoura, 35116, Egypt. hanymarei@mans.edu.eg.Egypt
- 文献类型
- 综述
- 期刊
- Cancer cell international2025 Jan 4
- 原文标识
- PubMed 39755633 · DOI 10.1186/s12935-024-03615-8
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