TP53 缺失通过上调 NF-κB-IFN-β-MHC-Ia 信号促进骨肉瘤对 NK 细胞的抵抗
TP53 Loss Elevates NF-κB-IFN-β-MHC-Ia Signaling to Promote NK Cell Resistance in Osteosarcoma.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
用于增强金属有机框架纳米颗粒肿瘤治疗疗效的间充质干细胞膜衍生复合系统
英文原题：Mesenchymal Stem Cell Membrane-Derived Composite System for Enhancing the Tumor Treatment Efficacy of Metal-Organic Framework Nanoparticles.
查看英文原题
Mesenchymal Stem Cell Membrane-Derived Composite System for Enhancing the Tumor Treatment Efficacy of Metal-Organic Framework Nanoparticles.
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中文摘要
间充质干细胞（MSC）膜包被金属有机框架（MOF）是一种创新方法，可提高肿瘤细胞对铜基MOF（Cu-MOF）的摄取及治疗效力。利用MSC膜天然归巢能力和生物相容性，Cu-MOF可有效靶向肿瘤部位，促进细胞摄取增加。该包被不仅有助于癌细胞更有效地内化，还因铜离子递送增强而改善治疗结局。体外研究显示，与未包被Cu-MOF相比，MSC膜包被Cu-MOF（MSC-Cu-MOF）可显著增强对肿瘤细胞的细胞毒作用。这一新策略为提高癌症治疗的精准性和效力提供了有前景的新途径，显示出潜在肿瘤临床应用价值。
展开英文摘要原文
Mesenchymal stem cell (MSC) membrane-coated metal-organic frameworks (MOFs) represent an innovative approach to enhance the uptake and therapeutic efficacy of copper-based MOFs (Cu-MOFs) in tumor cells. By leveraging the natural homing abilities and biocompatibility of MSC membranes, Cu-MOFs can be effectively targeted to tumor sites, promoting increased cellular uptake.
This coating not only facilitates superior internalization by cancer cells but also augments the therapeutic outcomes due to the enhanced delivery of copper ions. In vitro studies demonstrate that MSC membrane-coated Cu-MOFs (MSC-Cu-MOFs) significantly improve the cytotoxic effects on tumor cells compared to uncoated Cu-MOFs. This novel strategy presents a promising avenue for advancing the precision and effectiveness of cancer treatment modalities, showcasing potential for clinical applications in oncology.
论文信息
- 作者
- Tong Y、Gao M、Luo Y
- 单位
- Wuxi School of Medicine, Jiangnan University, Wuxi 214122, Jiangsu, China.China
- 期刊
- IET nanobiotechnology2024
- 原文标识
- PubMed 39669228 · DOI 10.1049/nbt2/1069307
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