CAR-T(CAR-T)细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
英文原题:A Discount on the Cost of Cancer: India's Homegrown CAR-T Cell Therapy.
A Discount on the Cost of Cancer: India's Homegrown CAR-T Cell Therapy.
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CAR-T 细胞疗法改变了血液癌症治疗,通过改善B细胞恶性肿瘤患者生存,取得了传统化疗无法比拟的效果,为许多癌症患者带来希望。然而,采集、改造并回输T细胞成本高昂,许多需要CAR-T 治疗的癌症患者无力承担费用。部分中低收入国家还存在地理可及性限制且无法生产CAR-T 疗法;经济差异与地理限制共同扩大了癌症患者间的社会经济差距,长期以来成为问题。印度近期自主生产CAR-T 疗法,改变了这一状况。作为癌症负担沉重的中低收入国家,印度的NexCAR19是南亚癌症治疗史上的重要转折点。从惠及本国癌症患者,到与邻国合作,再到推动更多CAR-T 产品生产,NexCAR19促进了南亚对抗血液癌症的努力。
Chimeric antigen receptor T cell (CAR-T) therapy has revolutionized the treatment of blood cancer. By improving survival outcomes for patients with B-cell malignancies, which hitherto have been unparalleled by conventional chemotherapy, CAR-T therapy is a beacon of hope for many patients with cancer.
However, harvesting, modifying, and reintroducing T cells is costly, which means that not every patient with cancer who needs CAR-T therapy has the financial capacity to receive it. This blatant economic disparity, combined with geographical limitations, for several lower-middle-income countries that do not manufacture CAR-T therapy, has been a problem that has widened the socioeconomic gap between patients with cancer.
This was the case until India recently manufactured its own CAR-T therapy. As a lower-middle-income country with a massive burden of cancer, India's NexCAR19 was a pivotal point in South Asian cancer history. From benefiting local patients with cancer to collaborations with neighboring countries, to prompting the manufacture of more CAR-T products, NexCAR19 has facilitated the fight against blood cancers in South Asia.
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