RNF43 p.G659fs 通过 PI3K/AKT/mTOR 信号通路和 HLA-E 上调导致 MSI-high 结直肠癌中 NK 细胞功能障碍
RNF43 p.G659fs leads to natural killer cell dysfunction in MSI-high colorectal cancer through PI3K/AKT/mTOR signaling and HLA-E up-regulation.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
神经母细胞瘤中的 NK 细胞疗法
英文原题：Natural killer cell-based therapies in neuroblastoma.
查看英文原题
Natural killer cell-based therapies in neuroblastoma.
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中文摘要
神经母细胞瘤（NB）是儿童最常见的颅外实体瘤，约占所有儿童肿瘤的15%。尽管NB的治疗取得了进展，高危患者的预后仍然严峻。基于NK细胞的过继性细胞疗法正成为此类病例的辅助治疗手段。此外，也有证据表明基于NKT的疗法在NB的治疗中具有前景。与过继性T细胞疗法相比并发症更少、细胞来源多样以及多种肿瘤识别机制，是基于NK和NKT的疗法的一些优势。本综述致力于检索该领域的最新进展。
展开英文摘要原文
Neuroblastoma (NB) is the most common extracranial solid tumor of childhood forming around 15 % of all pediatric tumors. Despite advances in the treatment of NB, high-risk patients still face a grave prognosis. Adoptive cell therapies based on NK cells are becoming an assistive treatment for such cases.
Moreover, there is also evidence that NKT-based therapies have promising results in the management of NB. Lower complications in comparison with adoptive T cell therapies, various cell sources, and miscellaneous tumor recognition mechanisms are some of the advantages of NK- and NKT-based therapies. This review is dedicated to searching for recent advances in this field.
论文信息
- 作者
- Ghasempour A、Mohseni R、Sharif PM、Hamidieh AA
- 第一作者单位
- Pediatric Cell and Gene Therapy Research Center, Gene, Cell & Tissue Research Institute, Tehran University of Medical Sciences, Tehran, Iran.Iran
- 通讯作者单位
- Pediatric Cell and Gene Therapy Research Center, Gene, Cell & Tissue Research Institute, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: aahamidieh@tums.ac.ir.Iran
- 文献类型
- 综述
- 期刊
- Cellular immunology2025 Jan
- 原文标识
- PubMed 39631142 · DOI 10.1016/j.cellimm.2024.104898