基于 DNA 超分子水凝胶的保护性 NK 细胞储库用于增强三阴性乳腺癌治疗
Protective NK Cell Reservoir Based on DNA Supramolecular Hydrogel for Enhanced Triple-Negative Breast Cancer Therapy.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
乳腺癌中与 CD44 和 CD63 表达相关的临床病理特征
英文原题：Clinicopathological features associated with CD44 and CD63 expression in breast cancer.
查看英文原题
Clinicopathological features associated with CD44 and CD63 expression in breast cancer.
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研究概要
CD44 表达与侵袭性特征及低 CD63 密度染色相关。
中文摘要
背景
CD44 是一种细胞表面跨膜糖蛋白，参与调节多种细胞过程，包括细胞分裂、黏附、迁移和干细胞样特征。CD63 参与胞吐过程。
目的
评估 CD44 和 CD63 表达与临床病理特征（包括TIL（肿瘤浸润淋巴细胞）[TIL]）、磷脂酰肌醇 3-激酶（PIK3CA）突变和生存之间的关系。
方法
对 101 例秘鲁女性乳腺癌患者样本进行 CD44 和 CD63 染色。
结果
年龄中位数为 52 岁，多数患者为 3 级肿瘤（68%）、雌激素受体（ER）阳性（64%）和 II–III 期（92%）。Ki-67 中位数为 30%，间质 TIL 中位数为 30%，49% 患者存在 PIK3CA 突变。较长生存与早期分期（p = 0.016）、Ki-67 较低（p = 0.023）、ER 阳性（p = 0.034）、管腔型表型（p = 0.029）和复发（p < 0.001）相关。57% 病例 CD44 染色细胞密度高，55% 染色强度高。CD44 高密度与年龄较轻（p = 0.043）、三阴性表型（p = 0.035）和较短生存（p = 0.005）相关。CD44 高表达也与生存期短相关（p = 0.005）。56% 病例 CD63 细胞密度高，且与 ER 阳性（p = 0.045）、TIL 水平低（p = 0.007）、管腔 A 型（p = 0.015）和 CD44 染色强度低（p = 0.032）相关。
结论
CD44 表达与侵袭性特征以及 CD63 染色密度低相关。
展开英文摘要原文
BACKGROUND
CD44 is a cell-surface transmembrane glycoprotein that participates in the regulation of many cellular processes, including cell division, adhesion, migration and stem-like characteristics. CD63 is involved in the exocytosis process.
OBJECTIVE
To evaluate the relationship between CD44 and CD63 expression and clinicopathological features, including tumor-infiltrating lymphocytes (TILs), phosphoinositide 3-kinase (PIK3CA) mutation and survival. METHODOLOGY: CD44 and CD63 were stained in samples from 101 breast cancer cases from Peruvian women.
RESULTS
Median age was 52 years, most were most were grade-3 (68%), estrogen receptor (ER)+ (64%) and stage II-III (92%). Median ki67 was 30%, median stromal TIL was 30% and PIK3CA mutation was found in 49%. Longer survival was associated with earlier stages ( p = 0.016), lower ki67 ( p = 0.023), ER+ ( p = 0.034), luminal phenotype ( p = 0.029) and recurrence ( p < 0.001). CD44 was classified as high cell density staining in 57% and high intensity in 55%. High CD44 density was associated with younger age ( p = 0.043), triple-negative phenotype ( p = 0.035) and shorter survival ( p = 0.005). High CD44 expression was associated with short survival ( p = 0.005). High CD63 cell density was found in 56% of cases and was associated with ER-positive ( p = 0.045), low TIL levels ( p = 0.007), Luminal-A ( p = 0.015) and low CD44 intensity ( p = 0.032).
CONCLUSION
CD44 expression was associated with aggressive features and low CD63 density staining.
论文信息
- 作者
- Castaneda CA、Castillo M、Sanchez J、Bernabe L、Tello K、Suarez N、Alatrista R、Quiroz-Gil X
- 第一作者单位
- Faculty of Health Sciences, Universidad Cientifica del Sur, Lima 15067, Peru.
- 通讯作者单位
- Unidad de Ensayos Clinicos, Oncosalud-AUNA, Lima 15038, Peru.
- 期刊
- Ecancermedicalscience2024
- 原文标识
- PubMed 39430073 · DOI 10.3332/ecancer.2024.1779
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