RNF43 p.G659fs 通过 PI3K/AKT/mTOR 信号通路和 HLA-E 上调导致 MSI-high 结直肠癌中 NK 细胞功能障碍
RNF43 p.G659fs leads to natural killer cell dysfunction in MSI-high colorectal cancer through PI3K/AKT/mTOR signaling and HLA-E up-regulation.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
英文原题:Immunotherapy for colorectal cancer.
Immunotherapy for colorectal cancer.
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结直肠癌是世界上第三大常见癌症,也是第二大最致命的癌症。该疾病的主要病因是饮食和行为因素。这种复杂疾病的治疗主要基于传统疗法,包括手术、放疗和化疗。由于其高患病率和高发病率,迫切需要更有效且副作用更少的治疗方法。近年来,免疫疗法已成为一种潜在的治疗替代方案,也是发展最快的治疗方法之一。免疫疗法通过激活或增强免疫系统来识别和攻击癌细胞,从而抑制肿瘤生长。本综述介绍了免疫检查点抑制剂、细胞疗法、TIL(肿瘤浸润淋巴细胞)和溶瘤病毒的最新免疫疗法。其中一些已在临床试验中显示出有希望的结果,并已用于临床治疗。
Colorectal cancer is the third most common cancer and the second most lethal cancer in the world. The main cause of the disease is due to dietary and behavioral factors. The treatment of this complex disease is mainly based on traditional treatments, including surgery, radiotherapy, and chemotherapy. Due to its high prevalence and high morbidity, more effective treatments with fewer side effects are urgently needed.
In recent years, immunotherapy has become a potential therapeutic alternative and one of the fastest-developing treatments. Immunotherapy inhibits tumor growth by activating or enhancing the immune system to recognize and attack cancer cells. This review presents the latest immunotherapies for immune checkpoint inhibitors, cell therapy, tumor-infiltrating lymphocytes, and oncolytic viruses. Some of these have shown promising results in clinical trials and are used in clinical treatment.
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