单细胞追踪揭示黑色素瘤 TIL 治疗过程中肿瘤反应性 T 细胞的可塑性
Single-cell tracking reveals tumor-reactive T cell plasticity during melanoma TIL therapy.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
转化胰胆管癌治疗：探索过继性细胞疗法和癌症疫苗的前沿
英文原题：Transforming pancreaticobiliary cancer treatment: Exploring the frontiers of adoptive cell therapy and cancer vaccines.
查看英文原题
Transforming pancreaticobiliary cancer treatment: Exploring the frontiers of adoptive cell therapy and cancer vaccines.
分数与星级只用于站内排序 —— 不代表疗效、安全性或个人适用性。
中文摘要
胰胆癌包括胰腺和胆道的恶性肿瘤，是一项严峻的临床挑战，其预后一致黯淡。其早期阶段的无症状特性常导致延迟发现，造成不利的5年总生存率。传统治疗方式疗效有限，凸显了对替代治疗方法的迫切需求。近年来，免疫治疗已成为抗击胰胆癌的一条有前景的途径。治疗性疫苗和使用TIL（肿瘤浸润淋巴细胞）等策略因其引发更强效、更持久反应的潜力而受到关注。本综述旨在阐明新兴免疫治疗干预的图景，从临床和研究角度提供见解。通过加深我们对胰胆癌的理解并探索创新治疗模式，我们旨在促进患者预后和生活质量的改善。
展开英文摘要原文
Pancreaticobiliary cancer, encompassing malignancies of both the pancreatic and biliary tract, presents a formidable clinical challenge marked by a uniformly bleak prognosis. The asymptomatic nature of its early stages often leads to delayed detection, contributing to an unfavorable 5-year overall survival rate. Conventional treatment modalities have shown limited efficacy, underscoring the urgent need for alternative therapeutic approaches. In recent years, immunotherapy has emerged as a promising avenue in the fight against pancreaticobiliary cancer.
Strategies such as therapeutic vaccines and the use of tumor-infiltrating lymphocytes have garnered attention for their potential to elicit more robust and durable responses. This review seeks to illuminate the landscape of emerging immunotherapeutic interventions, offering insights from both clinical and research perspectives. By deepening our understanding of pancreaticobiliary cancer and exploring innovative treatment modalities, we aim to catalyze improvements in patient outcomes and quality of life.
论文信息
- 作者
- Amhis N、Carignan J、Tai LH
- 单位
- Department of Immunology and Cell Biology, Université de Sherbrooke, Sherbrooke, QC J1E 4K8, Canada.Canada
- 文献类型
- 综述
- 期刊
- Molecular therapy. Oncology2024 Sep 19
- 原文标识
- PubMed 39006944 · DOI 10.1016/j.omton.2024.200825
在 PubMed 查看 → 出版商原文（DOI） 全文 PDF（PMC）· 可下载 治疗专题与资料阅读指南 资料来源与翻译说明 报告译文或资料问题 →