基于 DNA 超分子水凝胶的保护性 NK 细胞储库用于增强三阴性乳腺癌治疗
Protective NK Cell Reservoir Based on DNA Supramolecular Hydrogel for Enhanced Triple-Negative Breast Cancer Therapy.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
一项多中心方案，用于评估肿瘤微环境在喉鳞状细胞癌患者中的预后意义
英文原题：A multicenter protocol to assess the prognostic significance of the tumor microenvironment in patients with squamous cell carcinoma of the larynx.
查看英文原题
A multicenter protocol to assess the prognostic significance of the tumor microenvironment in patients with squamous cell carcinoma of the larynx.
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研究概要
我们的研究证实了 TILs 在 LSCC 中的保护价值以及肿瘤微环境的预后作用；此外，我们的结果表明，国际 TILs 工作组针对乳腺癌提出的评分可应用于 LSCC。
研究思路结论见上方概要
背景
这项多中心研究的目的是，采用国际TILs工作组在乳腺癌中提出的方法，在一个大型喉鳞状细胞癌（LSCC）患者队列中，回顾性研究肿瘤微环境与生存相关的预后意义。
方法
研究回顾性纳入2014年1月至2023年1月期间所有经活检证实为LSCC并接受全喉切除术（TL）的连续患者。对包括手术、病理和随访报告在内的医疗记录进行了回顾性审查。TILs的密度根据国际TILs工作组的建议确定。
结果
研究组包括186例LSCC患者。高TILs与原发性肿瘤体积缩小和范围减少（pT分期）具有统计学相关性，且具有统计学显著性（S：p = 0.01；P：p = 0.0003），并且无需挽救治疗（S：p = 0.03；P：p = 0.004）。低TILs提示预后较差。
展开英文摘要原文
BACKGROUND
The purpose of this multicenter study was to retrospectively investigate the prognostic significance of the tumor microenvironment, in relation to survival in a large cohort of patients with laryngeal squamous cell carcinoma (LSCC), using the method proposed by the International TILs Working Group in breast cancer.
METHODS
All consecutive patients with biopsy-proven LSCC who underwent total laryngectomy (TL) between January 2014 and January 2023 were retrospectively included in the study. A retrospective review of medical records including surgical, pathological and follow-up reports was performed. The density of TILs was determined according to the recommendations of the International TILs Working Group.
RESULTS
The study group included 186 patients with LSCC. High TILs were statistically correlated with reduced size and extension of primary tumor (pT stage) with a statistically significant value (S: p = 0.01; P: p = 0.0003) and without needs of salvage therapy (S: p = 0.03; P: p = 0.004). Low TILs were indicative of worse prognosis.
CONCLUSIONS
Our study confirmed the protective value of TILs and the prognostic role of the tumor microenvironment in LSCC; furthermore, our results showed that the score proposed by the International TILs Working Group for breast cancer can be applied to LSCC.
论文信息
- 作者
- De Luca P、Di Stadio A、Petruzzi G、de Campora L、Fior M、Moretti C、Della Peruta V、Mazzola F
- 第一作者单位
- Department of Otolaryngology, Isola Tiberina - Gemelli Isola Hospital, Rome, Italy.Italy
- 通讯作者单位
- Department of Otolaryngology, San Giovanni-Addolorata Hospital, Rome, Italy.Italy
- 文献类型
- 临床试验方案
- 期刊
- Head & neck2024 Sep
- 原文标识
- PubMed 38958199 · DOI 10.1002/hed.27860