基于 DNA 超分子水凝胶的保护性 NK 细胞储库用于增强三阴性乳腺癌治疗
Protective NK Cell Reservoir Based on DNA Supramolecular Hydrogel for Enhanced Triple-Negative Breast Cancer Therapy.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
转移的守护者与介导者：探索乳腺癌微环境中的 T 淋巴细胞、髓源性抑制细胞和肿瘤相关巨噬细胞
英文原题：Guardians and Mediators of Metastasis: Exploring T Lymphocytes, Myeloid-Derived Suppressor Cells, and Tumor-Associated Macrophages in the Breast Cancer Microenvironment.
查看英文原题
Guardians and Mediators of Metastasis: Exploring T Lymphocytes, Myeloid-Derived Suppressor Cells, and Tumor-Associated Macrophages in the Breast Cancer Microenvironment.
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中文摘要
乳腺癌（BC）是由癌细胞和不断变化的肿瘤微环境（TME）组成的异质性组织构成的实体瘤。TME包括除癌细胞外的其他非癌细胞类型，其中包括影响癌症组织免疫背景的免疫细胞。特别是，免疫细胞之间的交互作用及其与癌细胞的相互作用显著影响BC的播散、免疫编辑和癌症治疗的结果。TIL（肿瘤浸润淋巴细胞）（TILs）、肿瘤相关巨噬细胞（TAMs）和髓源性抑制细胞（MDSCs）代表了乳腺TME中突出的免疫细胞群体，它们在癌症免疫逃逸和播散中具有重要作用。因此，在本文中，我们综述了BC中TILs、TAMs和MDSCs的特征。此外，我们重点介绍了这些免疫细胞重塑免疫TME并导致乳腺癌转移的机制。
展开英文摘要原文
Breast cancers (BCs) are solid tumors composed of heterogeneous tissues consisting of cancer cells and an ever-changing tumor microenvironment (TME). The TME includes, among other non-cancer cell types, immune cells influencing the immune context of cancer tissues.
In particular, the cross talk of immune cells and their interactions with cancer cells dramatically influence BC dissemination, immunoediting, and the outcomes of cancer therapies. Tumor-infiltrating lymphocytes (TILs), tumor-associated macrophages (TAMs), and myeloid-derived suppressor cells (MDSCs) represent prominent immune cell populations of breast TMEs, and they have important roles in cancer immunoescape and dissemination.
Therefore, in this article we review the features of TILs, TAMs, and MDSCs in BCs.
Moreover, we highlight the mechanisms by which these immune cells remodel the immune TME and lead to breast cancer metastasis.
论文信息
- 作者
- Ruocco MR、Gisonna A、Acampora V、D'Agostino A、Carrese B、Santoro J、Venuta A、Nasso R
- 第一作者单位
- Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, 80131 Naples, Italy.Italy
- 通讯作者单位
- Department of Experimental and Clinical Medicine, University of Catanzaro "Magna Graecia", 88100 Catanzaro, Italy.Italy
- 文献类型
- 综述
- 期刊
- International journal of molecular sciences2024 Jun 5
- 原文标识
- PubMed 38892411 · DOI 10.3390/ijms25116224
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