CELL INTELLIGENCE · 肿瘤细胞治疗研究

CELLIN 肿瘤细胞治疗研究

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预后生物标志物 TIL（肿瘤浸润淋巴细胞）未能作为完全切除 pN2 非小细胞肺癌术后放疗的预测生物标志物：一项回顾性分析

英文原题：Prognostic biomarker tumor-infiltrating lymphocytes failed to serve as a predictive biomarker for postoperative radiotherapy in completely resected pN2 non-small cell lung cancer: a retrospective analysis.

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Prognostic biomarker tumor-infiltrating lymphocytes failed to serve as a predictive biomarker for postoperative radiotherapy in completely resected pN2 non-small cell lung cancer: a retrospective analysis.

PubMed 2024/06/17（内容时间） Respir Res Q1 · IF 5.7（JCR 2025）

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非小细胞肺癌地区：中国
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研究概要

用 H&E 切片评估的 TILs 可能代表完全切除的 pN2 NSCLC 患者的预后生物标志物，高 TILs 浸润与有利的生存结局相关。TILs 对 PORT 的预测价值仍需在未来进一步探索。

中文摘要

背景

证据表明，放疗是非小细胞肺癌（NSCLC）中一种强效免疫调节剂。反之，免疫浸润能否影响放疗疗效则鲜有研究。本研究探讨TIL（肿瘤浸润淋巴细胞）对完全切除的 III 期 pN2 NSCLC 患者术后放疗（PORT）反应的影响。

方法

这项回顾性研究纳入本机构 2014 至 2020 年间接受完全切除、病理确诊 III-N2 期 NSCLC 的 244 例患者。使用全切面常规苏木精-伊红（H&E）染色切片评估 TIL，并依据已发表指南进行判读。以 50% 为界值将患者分为 TIL 低组和 TIL 高组。采用 Kaplan-Meier 法和 Log-rank 检验评估无病生存期（DFS）和总生存期（OS），并采用单变量及多变量 Cox 回归分析确定预后指标。

结果

244 例患者中，121 例接受 PORT，123 例未接受。PORT 患者 TIL 水平显著高于未接受 PORT 患者（p<0.001）。在全队列（DFS，p<0.001；OS，p=0.001）、PORT 队列（DFS，p=0.003；OS，p=0.011）和未接受 PORT 队列（DFS，p<0.001；OS，p=0.034）中，TIL 水平高均与 DFS 和 OS 改善显著相关。在 TIL 浸润低组（DFS，p=0.244；OS，p=0.404）和高组（DFS，p=0.167；OS，p=0.958）中，不同治疗方式的生存差异均无统计学意义。

结论

通过 H&E 切片评估的 TIL 可作为完全切除 pN2 NSCLC 患者的预后生物标志物；TIL 浸润较高与良好生存结局相关。TIL 对 PORT 的预测价值仍需未来进一步探索。

展开英文摘要原文
BACKGROUND

Evidence suggests that radiotherapy is a potent immunomodulator in non-small cell lung cancer (NSCLC). Conversely, it has rarely been demonstrated if immune infiltration can influence radiotherapy efficacy. Herein, we explored the effect of tumor-infiltrating lymphocytes (TILs) on the response to postoperative radiotherapy (PORT) in completely resected stage III-pN2 NSCLC.

METHODS

This retrospective study included 244 patients with pathologically confirmed stage III-N2 NSCLC who underwent complete resection at our institution between 2014 and 2020. TILs were assessed with permanent full-face hematoxylin and eosin (H&E) sections and the evaluation of TILs was based on a published guideline. Patients were stratified into the TIL low or TIL high group with a cutoff value of 50%. Kaplan-Meier method and Log-rank test were utilized to assess disease-free survival (DFS) and overall survival (OS). Univariate and multivariate Cox regression analysis were conducted to determine prognostic indicators.

RESULTS

Among 244 patients, a total of 121 patients received PORT whereas 123 did not. TILs level in patients with PORT was significantly higher than that in patients without PORT (p < 0.001). High TILs level was significantly associated with an improved DFS and OS in all the entire chort (DFS, p < 0.001; OS, p = 0.001), PORT chort (DFS, p = 0.003; OS, p = 0.011) and non-PORT chort (DFS, p < 0.001; OS, p = 0.034). There were no significant survival differences between different treatment modalities in the low TILs infiltration (DFS, p = 0.244; OS, p = 0.404) and high TILs infiltration (DFS, p = 0.167; OS, p = 0.958) groups.

CONCLUSIONS

TILs evaluated with H&E sections could represent a prognostic biomarker in patients with completely resected pN2 NSCLC, and high TILs infiltration was associated with favorable survival outcomes.The predictive value of TILs for PORT still need to be further explored in the future.

论文信息

作者
Li J、Li L、Wang J、Liu N、Liu H、Xu F、Li M、Yuan S
第一作者单位
Shandong University Cancer Center, Jinan, Shandong, China.China
通讯作者单位
Department of Radiation Oncology, Shandong Provincial Key Laboratory of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University, Shandong Academy of Medical Sciences, Jinan, Shandong, China. yuanshuanghu@sina.com.China
期刊
Respiratory research2024 Jun 17
原文标识
PubMed 38886760　·　DOI 10.1186/s12931-024-02863-6

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