RNF43 p.G659fs 通过 PI3K/AKT/mTOR 信号通路和 HLA-E 上调导致 MSI-high 结直肠癌中 NK 细胞功能障碍
RNF43 p.G659fs leads to natural killer cell dysfunction in MSI-high colorectal cancer through PI3K/AKT/mTOR signaling and HLA-E up-regulation.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
结直肠癌 TIL 治疗的研究进展
英文原题：Research advances on TIL therapy for colorectal cancer.
查看英文原题
Research advances on TIL therapy for colorectal cancer.
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中文摘要
结直肠癌（CRC）是一种常见的胃肠道恶性肿瘤。TIL（肿瘤浸润淋巴细胞）疗法是一种过继细胞疗法（ACT），通过从肿瘤组织中分离 T 淋巴细胞、在体外扩增后再回输至体内，以靶向并清除肿瘤细胞。本文概述 TIL 疗法在 CRC 中的发展与应用，以及相关挑战。
展开英文摘要原文
Colorectal cancer (CRC) is a prevalent gastrointestinal malignancy. Tumor-infiltrating lymphocyte (TIL) therapy, a form of adoptive cellular therapy (ACT), involves isolating T lymphocytes from tumor tissues, in vitro expansion, and reintroduction into the body to target and eliminate tumor cells. This article presents an overview of the development and application of TIL therapy in CRC, as well as the associated challenges.
论文信息
- 作者
- Jiang J、Shu W、Yao Q
- 第一作者单位
- The Second Clinical Medical College of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.China
- 通讯作者单位
- The Second Affiliated Hospital of Zhejiang Chinese Medical University, Xinhua Hospital of Zhejiang Province, Hangzhou, Zhejiang, China. 20234052@zcmu.edu.cn.China
- 文献类型
- 综述
- 期刊
- Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico2024 Dec
- 原文标识
- PubMed 38806995 · DOI 10.1007/s12094-024-03530-4