基于 DNA 超分子水凝胶的保护性 NK 细胞储库用于增强三阴性乳腺癌治疗
Protective NK Cell Reservoir Based on DNA Supramolecular Hydrogel for Enhanced Triple-Negative Breast Cancer Therapy.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
英文原题:Enhancing AI Research for Breast Cancer: A Comprehensive Review of Tumor-Infiltrating Lymphocyte Datasets.
Enhancing AI Research for Breast Cancer: A Comprehensive Review of Tumor-Infiltrating Lymphocyte Datasets.
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免疫学是理解肿瘤微环境复杂动态的基础。尤其在乳腺癌中,评估TIL(肿瘤浸润淋巴细胞)至关重要。为获得全面认识,采用计算机辅助病理学(CAP)工具对 TIL 进行定量已成为重要方法,相关工具运用基于深度学习的先进人工智能模型。要可靠识别 TIL,必须对模型进行训练,这需要获取带标注的数据集。然而,创建此类数据集不仅受其稀缺限制,标注过程本身也十分耗时。本综述旨在考察 TIL 领域可公开获取的数据集,从而为 TIL 研究群体提供有价值的资源。因此,本综述的总体目标是检查和评估现有公开在线数据集,使当前及未来的 CAP 工具更易于训练和验证,从而用于 TIL 评估。
The field of immunology is fundamental to our understanding of the intricate dynamics of the tumor microenvironment. In particular, tumor-infiltrating lymphocyte (TIL) assessment emerges as essential aspect in breast cancer cases. To gain comprehensive insights, the quantification of TILs through computer-assisted pathology (CAP) tools has become a prominent approach, employing advanced artificial intelligence models based on deep learning techniques.
The successful recognition of TILs requires the models to be trained, a process that demands access to annotated datasets. Unfortunately, this task is hampered not only by the scarcity of such datasets, but also by the time-consuming nature of the annotation phase required to create them.
Our review endeavors to examine publicly accessible datasets pertaining to the TIL domain and thereby become a valuable resource for the TIL community. The overall aim of the present review is thus to make it easier to train and validate current and upcoming CAP tools for TIL assessment by inspecting and evaluating existing publicly available online datasets.
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