TP53 缺失通过上调 NF-κB-IFN-β-MHC-Ia 信号促进骨肉瘤对 NK 细胞的抵抗
TP53 Loss Elevates NF-κB-IFN-β-MHC-Ia Signaling to Promote NK Cell Resistance in Osteosarcoma.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
英文原题:A case series on safety and tolerability of human umbilical cord-derived mesenchymal stem cells on patients in Malaysia.
A case series on safety and tolerability of human umbilical cord-derived mesenchymal stem cells on patients in Malaysia.
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脐带来源间充质干细胞(MSC)用于再生治疗,是慢性疾病的一种有前景的治疗选择。与其他来源相比,脐带 MSC 具有多项优势,因此适用于组织修复和再生。本临床研究报告马来西亚 9 例患者接受脐带 MSC 治疗后 1 年的安全性和耐受性。研究评估不良反应,并于治疗前后进行肝功能检查,通过随访评估 MSC 疗法的有效性和安全性。所有 9 例患者对脐带 MSC 治疗均有良好反应,且未出现不良反应。治疗后肝功能检查结果显著改善,血液学参数和肿瘤标志物保持稳定。本研究认为马来西亚患者对脐带 MSC 疗法耐受良好;但仍需在更大规模患者群体中进一步开展临床评估。
Umbilical cord-derived mesenchymal stem cells for regenerative therapy are a promising treatment option for chronic illnesses. Umbilical cord-derived mesenchymal stem cells offer several advantages over other sources, which makes them an attractive option in tissue repair and regeneration. This clinical study describes a 1-year follow-up on the safety and tolerance of umbilical cord-derived mesenchymal stem cell therapy on nine patients in Malaysia. Patients were assessed for adverse effects, and liver function tests were carried out on both pre- and post-treatments.
Umbilical cord-derived mesenchymal stem cells' effectiveness and safety were assessed by follow-up evaluations. All nine patients responded positively towards umbilical cord-derived mesenchymal stem cell therapy, without any adverse effects.
After umbilical cord-derived mesenchymal stem cell therapy, a significant improvement was observed in liver functioning test outcomes, as haematological parameters and tumour markers were stable. The present study concludes that umbilical cord-derived mesenchymal stem cell therapy is well tolerated by Malaysian patients; however, further clinical screening must be done over a large number of patients population.
在 PubMed 查看 → 出版商原文(DOI) 全文 PDF(PMC)· 可下载 治疗专题与资料阅读指南 资料来源与翻译说明 报告译文或资料问题 →
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