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人脐带来源间充质干细胞在马来西亚患者中的安全性与耐受性病例系列

英文原题:A case series on safety and tolerability of human umbilical cord-derived mesenchymal stem cells on patients in Malaysia.

查看英文原题

A case series on safety and tolerability of human umbilical cord-derived mesenchymal stem cells on patients in Malaysia.

PubMed 2024/04/29(内容时间) SAGE Open Med Case Rep Q3 · IF 0.6(JCR 2025)

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中文摘要

脐带来源间充质干细胞(MSC)用于再生治疗,是慢性疾病的一种有前景的治疗选择。与其他来源相比,脐带 MSC 具有多项优势,因此适用于组织修复和再生。本临床研究报告马来西亚 9 例患者接受脐带 MSC 治疗后 1 年的安全性和耐受性。研究评估不良反应,并于治疗前后进行肝功能检查,通过随访评估 MSC 疗法的有效性和安全性。所有 9 例患者对脐带 MSC 治疗均有良好反应,且未出现不良反应。治疗后肝功能检查结果显著改善,血液学参数和肿瘤标志物保持稳定。本研究认为马来西亚患者对脐带 MSC 疗法耐受良好;但仍需在更大规模患者群体中进一步开展临床评估。

展开英文摘要原文

Umbilical cord-derived mesenchymal stem cells for regenerative therapy are a promising treatment option for chronic illnesses. Umbilical cord-derived mesenchymal stem cells offer several advantages over other sources, which makes them an attractive option in tissue repair and regeneration. This clinical study describes a 1-year follow-up on the safety and tolerance of umbilical cord-derived mesenchymal stem cell therapy on nine patients in Malaysia. Patients were assessed for adverse effects, and liver function tests were carried out on both pre- and post-treatments.

Umbilical cord-derived mesenchymal stem cells' effectiveness and safety were assessed by follow-up evaluations. All nine patients responded positively towards umbilical cord-derived mesenchymal stem cell therapy, without any adverse effects.

After umbilical cord-derived mesenchymal stem cell therapy, a significant improvement was observed in liver functioning test outcomes, as haematological parameters and tumour markers were stable. The present study concludes that umbilical cord-derived mesenchymal stem cell therapy is well tolerated by Malaysian patients; however, further clinical screening must be done over a large number of patients population.

论文信息

作者
Yusof B、Kamal I、Lee KM、Chai SK、Zuo XL、Ravichandran M、Ding KX、Fuloria NK
第一作者单位
ALPS Medical Centre, ALPS Global Holding, Kuala Lumpur, Malaysia.Malaysia
通讯作者单位
ALPS Global Holding Berhad, Kuala Lumpur, Malaysia.Malaysia
文献类型
病例报告
期刊
SAGE open medical case reports2024
原文标识
PubMed 38694904 · DOI 10.1177/2050313X241249622