基于 DNA 超分子水凝胶的保护性 NK 细胞储库用于增强三阴性乳腺癌治疗
Protective NK Cell Reservoir Based on DNA Supramolecular Hydrogel for Enhanced Triple-Negative Breast Cancer Therapy.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
「基底样」形态、TIL（肿瘤浸润淋巴细胞）与多 MAGE-A 表达在三阴性乳腺癌中的预后价值
英文原题：Prognostic Value of "Basal-like" Morphology, Tumor-Infiltrating Lymphocytes and Multi-MAGE-A Expression in Triple-Negative Breast Cancer.
查看英文原题
Prognostic Value of "Basal-like" Morphology, Tumor-Infiltrating Lymphocytes and Multi-MAGE-A Expression in Triple-Negative Breast Cancer.
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中文摘要
“基底样”（BL）形态和乳腺癌癌睾抗原（CTA）表达的预后意义仍不明确。本研究旨在探讨三阴性乳腺癌（TNBC）组织学形态及肿瘤微环境与多重 MAGE-A CTA 表达的相关性，并评估其预后意义。研究分析了 2017 年 1 月至 2018 年 12 月期间在克罗地亚 4 家主要临床中心接受手术的乳腺癌患者临床资料，共纳入 97 例有组织样本和治疗信息的非转移性 TNBC。肿瘤组织切片另行进行程序性死亡配体 1（PD-L1）Ventana（SP142）和多重 MAGE-A（mAb 57B）染色。47 例（49%）TNBC 显示 BL 形态，并与较高 Ki-67 增殖指数和组织学分级相关。77 例（79%）表达多重 MAGE-A，且与 BL 形态显著相关。11 例（11.3%）符合淋巴细胞为主型乳腺癌（LPBC），该状态与 Ki-67 增殖指数、瘤内淋巴细胞（itTIL）数量增加及 PD-L1 表达显著相关。BL 形态、多重 MAGE-A 表达、组织学类型或 LPBC 状态均未影响无病生存期。数据提示，肿瘤形态可帮助识别可能从 CTA 靶向免疫治疗中获益的患者。
展开英文摘要原文
"Basal-like" (BL) morphology and the expression of cancer testis antigens (CTA) in breast cancer still have unclear prognostic significance. The aim of our research was to explore correlations of the morphological characteristics and tumor microenvironment in triple-negative breast carcinomas (TNBCs) with multi-MAGE-A CTA expression and to determine their prognostic significance. Clinical records of breast cancer patients who underwent surgery between January 2017 and December 2018 in four major Croatian clinical centers were analyzed. A total of 97 non-metastatic TNBCs with available tissue samples and treatment information were identified.
Cancer tissue sections were additionally stained with programmed death-ligand 1 (PD-L1) Ventana (SP142) and multi-MAGE-A (mAb 57B). BL morphology was detected in 47 (49%) TNBCs and was associated with a higher Ki-67 proliferation index and histologic grade. Expression of multi-MAGE-A was observed in 77 (79%) TNBCs and was significantly associated with BL morphology.
Lymphocyte-predominant breast cancer (LPBC) status was detected in 11 cases (11. 3%) and significantly correlated with the Ki-67 proliferation index, increased number of intratumoral lymphocytes (itTIL), and PD-L1 expression. No impact of BL morphology, multi-MAGE-A expression, histologic type, or LPBC status on disease-free survival was observed.
Our data suggest that tumor morphology could help identify patients with potential benefits from CTA-targeting immunotherapy.
论文信息
- 作者
- Čeprnja T、Tomić S、Perić Balja M、Marušić Z、Blažićević V、Spagnoli GC、Juretić A、Čapkun V
- 单位
- Department of Pathology, Forensic Medicine and Cytology, University Hospital of Split, 21000 Split, Croatia.
- 期刊
- International journal of molecular sciences2024 Apr 20
- 原文标识
- PubMed 38674098 · DOI 10.3390/ijms25084513
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