基于 DNA 超分子水凝胶的保护性 NK 细胞储库用于增强三阴性乳腺癌治疗
Protective NK Cell Reservoir Based on DNA Supramolecular Hydrogel for Enhanced Triple-Negative Breast Cancer Therapy.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
程序性死亡配体 1 在三阴性女性乳腺癌中是否具有预后意义？
英文原题：Is Programmed Death-Ligand 1 of Prognostic Significance in Triple-Negative Female Mammary Carcinoma?
查看英文原题
Is Programmed Death-Ligand 1 of Prognostic Significance in Triple-Negative Female Mammary Carcinoma?
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研究概要
PD-L1 表达于具有高级别、晚期 T 分期和高 Ki-67 指数等不良预后特征的肿瘤中，TILs PD-L1 阳性病例的生存得到改善，支持其预后意义。
中文摘要
目的
研究女性TNBC中间质TIL（肿瘤浸润淋巴细胞）和肿瘤细胞（TC）程序性死亡配体1（PD-L1）的免疫组化表达，并分析其与肿瘤病理特征的相关性，特别是肿瘤分级、分期和总生存期等反映生物学行为的特征。
方法
本回顾性研究纳入49份石蜡包埋肿瘤组织切片，来自接受根治性或保守性乳腺手术的女性TNBC患者。通过免疫组化分析PD-L1表达。
结果
TC中PD-L1表达与TIL中PD-L1表达显著相关；TIL中PD-L1表达与组织学分级、间质TIL及Ki-67之间也存在显著相关性。TC中PD-L1表达与淋巴结（N）分期、组织学分级和解剖学分期显著相关。TIL PD-L1阳性病例生存有所改善；然而，TC和间质TIL中PD-L1表达与总生存期的相关性均未达到统计学显著性。
结论
PD-L1在具有不良预后特征的肿瘤中表达，例如高级别、较高T分期和Ki-67指数高。TIL PD-L1阳性病例生存较好，支持其预后意义；但与总生存期的相关性未达到统计学显著性。
展开英文摘要原文
RESULTS
There were statistically significant relations among TC PD-L1 expression and TILs PD-L1 expression as well as relations among TILs PD-L1 expression with histologic grade, stromal TILs, and Ki-67 were statistically significant. Correlations between TC PD-L1 expression and N stage, histologic grade, and anatomic stage were statistically significant. Improved survival was detected within TILs PD-L1-positive cases; however, the correlation between the overall survival and PD-L1 expression in both TCs and stromal TIL was not statistically significant.
CONCLUSION
PD-L1 expressed in tumors with poor prognostic features such as the high grade, advanced T stage, and high Ki-67 index, TILs PD-L1-positive cases experienced improved survival supporting its prognostic significance. However, the correlation with overall survival was not statistically significant.
论文信息
- 作者
- Sanad AM、Ibrahim WS、Ezzo IM、Sabry RM
- 第一作者单位
- Department of Pathology, Faculty of Medicine, Tanta Cancer Center, Tanta University, Tanta, Egypt.Egypt
- 通讯作者单位
- Department of Pathology, Faculty of Medicine, Cairo University, Cairo, Egypt.Egypt
- 期刊
- Journal of microscopy and ultrastructure2024 Jan-Mar
- 原文标识
- PubMed 38633572 · DOI 10.4103/jmau.jmau_77_21
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