基于 DNA 超分子水凝胶的保护性 NK 细胞储库用于增强三阴性乳腺癌治疗
Protective NK Cell Reservoir Based on DNA Supramolecular Hydrogel for Enhanced Triple-Negative Breast Cancer Therapy.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
乳腺癌中的抗癌免疫反应：当前和新兴的生物标志物与治疗
英文原题：The anti-cancer immune response in breast cancer: current and emerging biomarkers and treatments.
查看英文原题
The anti-cancer immune response in breast cancer: current and emerging biomarkers and treatments.
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中文摘要
三阴性乳腺癌（TNBC）表现出T细胞浸润增强，与其他亚型相比，有助于对免疫检查点阻断（ICB）产生更强的应答。免疫丰富的免疫微环境与早期和晚期TNBC预后改善相关。化疗联合ICB现已成为早期和晚期TNBC的标准治疗。尽管程序性死亡配体-1（PD-L1）阳性可预测晚期阶段的ICB应答，但其在早期疾病中的作用仍不确定。尽管新辅助ICB在早期TNBC中已变得常见，但术后辅助ICB的必要性仍不明确。理解乳腺癌免疫应答的分子基础对于ICB的精准生物标志物和有效的联合治疗策略至关重要。
展开英文摘要原文
Triple-negative breast cancers (TNBCs) exhibit heightened T cell infiltration, contributing to an enhanced response to immune checkpoint blockade (ICB) compared with other subtypes. An immune-rich immune microenvironment correlates with improved prognosis in early and advanced TNBC. Combination chemotherapy and ICB is now the standard of care in early- and late-stage TNBC.
Although programmed death ligand-1 (PD-L1) positivity predicts ICB response in advanced stages, its role in early-stage disease remains uncertain. Despite neoadjuvant ICB becoming common in early-stage TNBC, the necessity of adjuvant ICB after surgery remains unclear. Understanding the molecular basis of the immune response in breast cancer is vital for precise biomarkers for ICB and effective combination therapy strategies.
论文信息
- 作者
- Rayson VC、Harris MA、Savas P、Hun ML、Virassamy B、Salgado R、Loi S
- 第一作者单位
- Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.Australia
- 通讯作者单位
- Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia; The Sir Peter MacCallum Department of Medical Oncology, University of Melbourne, Melbourne, Victoria, Australia; Division of Cancer Research, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia. Electronic address: sherene.loi@petermac.org.Australia
- 文献类型
- 综述 · 非美国政府资助研究
- 期刊
- Trends in cancer2024 Jun
- 原文标识
- PubMed 38521654 · DOI 10.1016/j.trecan.2024.02.008