CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
以嵌合受体靶向实体瘤抗原：癌症生物学与合成免疫学的交汇
英文原题：Targeting solid tumor antigens with chimeric receptors: cancer biology meets synthetic immunology.
查看英文原题
Targeting solid tumor antigens with chimeric receptors: cancer biology meets synthetic immunology.
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中文摘要
嵌合抗原受体（CAR）T细胞疗法是B细胞恶性肿瘤治疗领域的一项医学突破。目前，针对实体瘤的CAR-T 细胞疗法的开发备受关注。尽管临床批准的CAR-T 细胞疗法靶向B细胞谱系抗原，但实体瘤靶点包括新抗原和在肿瘤生物学中具有多种作用的肿瘤相关抗原（TAA）。多项早期临床试验现已报告，靶向实体瘤的CAR-T 细胞疗法展现出令人鼓舞的疗效迹象。我们从癌症生物学和基因调控的角度综述了实体瘤靶抗原的全景，并结合了靶向这些抗原的CAR-T 细胞的新兴临床数据。随后，我们讨论了新兴的合成生物学策略及其在新型细胞免疫疗法临床开发中的应用。
展开英文摘要原文
Chimeric antigen receptor (CAR) T cell therapy is a medical breakthrough in the treatment of B cell malignancies. There is intensive focus on developing solid tumor-targeted CAR-T cell therapies. Although clinically approved CAR-T cell therapies target B cell lineage antigens, solid tumor targets include neoantigens and tumor-associated antigens (TAAs) with diverse roles in tumor biology. Multiple early-stage clinical trials now report encouraging signs of efficacy for CAR-T cell therapies that target solid tumors.
We review the landscape of solid tumor target antigens from the perspective of cancer biology and gene regulation, together with emerging clinical data for CAR-T cells targeting these antigens.
We then discuss emerging synthetic biology strategies and their application in the clinical development of novel cellular immunotherapies.
论文信息
- 作者
- Kembuan GJ、Kim JY、Maus MV、Jan M
- 第一作者单位
- Cellular Immunotherapy Program, Cancer Center, Massachusetts General Hospital, Boston, USA; Harvard Medical School, Boston, MA, USA; Department of Pathology, Massachusetts General Hospital, Boston, MA, USA.United States
- 通讯作者单位
- Cellular Immunotherapy Program, Cancer Center, Massachusetts General Hospital, Boston, USA; Harvard Medical School, Boston, MA, USA; Department of Pathology, Massachusetts General Hospital, Boston, MA, USA; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA. Electronic address: mjan@mgh.harvard.edu.United States
- 文献类型
- 综述 · 美国 NIH 资助研究
- 期刊
- Trends in cancer2024 Apr
- 原文标识
- PubMed 38355356 · DOI 10.1016/j.trecan.2024.01.003
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